Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1041912 | 0.86 | MEN1 (0.43) | KMT2AHTTMEN1ADRA1DADRA1A | |
| SCHEMBL13134029 | 0.85 | SMN1; SMN2 (0.50) | KMT2AHTTMEN1ADRA1DADRA1A | |
| SCHEMBL13748719 | 0.81 | SMN1; SMN2 (0.53) | KMT2AHTTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5078987 | 0.80 | SMN1; SMN2 (0.70) | KMT2AHTTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7272538 | 0.79 | KDM4E (0.66) | KMT2AHTTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27752030 | 0.76 | ADRA1A (0.57) | ADRA1DADRA1AADRA1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL6644379 | 0.74 | P2RX7 (0.56) | ADRA1DADRA1AADRA1BALDH1A1HPGD | |
| SCHEMBL150008 | 0.74 | TSHR (0.75) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL29381824 | 0.74 | TSHR (0.75) | KMT2AMEN1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7982557 | 0.74 | NPC1 (0.52) | KMT2AHTTMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349827-B2 | Substituted dipyrido-pyrimido-diazepine and benzo-pyrido-pyrimido compounds | ARQULE, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2414360-A1 | SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114898-A1 | SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249108-A1 | SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249108-A1 | SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS | PDXK, DPYD, DHFR | KMT2A 1921/4885HTT 2273/4885MEN1 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.