SCHEMBL538425

SCHEMBL538425

O=C(O)c1c(I)cc2ccccc2c1O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.58
HSD17B10 Q99714 3/20 0.58
CYP1A2 P05177 2/20 0.58
MEN1 O00255 2/20 0.58
ALDH1A1 P00352 2/20 0.58
KMT2A Q03164 2/20 0.58
KDM4E B2RXH2 1/20 0.58
GLA P06280 1/20 0.58
CYP2C19 P33261 1/20 0.58
GRIN2D O15399 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIN2C Q14957 1/20 0.50
LDHA P00338 1/20 0.49
POLB P06746 1/20 0.46
GPR35 Q9HC97 1/20 0.46
ME2 P23368 1/20 0.46
ME1 P48163 1/20 0.46
ME3 Q16798 1/20 0.46
CDC25B P30305 2/20 0.45
CYP2D6 P10635 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11408011 0.83 CASP6 (0.42) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL31149178 0.81 CYP1A2 (0.62) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL245378 0.81 CYP1A2 (0.62) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL4980294 0.81 KMT2A (0.56) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL5179019 0.81 MEN1 (0.56) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL3926157 0.80 MEN1 (0.48) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL5375009 0.80 MEN1 (0.60) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL28060760 0.79 MEN1 (0.58) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL2791213 0.79 CYP1A2 (0.58) HPGDHSD17B10CYP1A2MEN1ALDH1A1
SCHEMBL8460754 0.78 MEN1 (0.58) HPGDHSD17B10CYP1A2MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023107965-A1 SALT AND SOLID FORMS OF 1-(2,5-DIMETHOXY-4-METHYLPHENYL)-2-AMINOPROPANE (DOM), 2,5-DIMETHOXY-4-IODOAMPHETAMINE (DOI), 2,5-DIMETHOXY-4-BROMOAMPHETAMINE (DOB), AND 2,5-DIMETHOXY-4-CHLOROAMPHETAMINE (DOC) TERRAN BIOSCIENCES, INC. (US) 2023-06-15 WO claimed
US-20260125390-A1 SOLID FORMS OF MACROCYCLIC COMPOUNDS, SALTS AND FORMULATIONS THEREOF, AND METHODS OF PREPARING AND USING THE SAME KURA ONCOLOGY INC (US) 2026-05-07 US disclosed
US-12521455-B2 Kisspeptin receptor (KISS1R) targeted therapeutics and uses thereof RADIONETICS ONCOLOGY, INC. (US) 2026-01-13 US disclosed
EP-4288433-A1 NOVEL COMPOUNDS Cerevance, Inc. (US) 2023-12-13 EP disclosed
WO-2023227867-A1 HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 Cerevance, Inc. (US) 2023-11-30 WO disclosed
EP-3236970-B1 NEW METAL COMPLEXES OF NOCARDAMINE AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS CHEVION MORDECHAI (IL) 2020-12-16 EP disclosed
EP-2490670-B1 COMPOSITION FOR INHALATION INNOVATA LTD (GB) 2019-04-17 EP disclosed
US-10188616-B2 Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same TEIKOKU PHARMA USA, INC. (US) 2019-01-29 US disclosed
US-20180289640-A1 Topical Sphingosine-1-Phosphate Receptor Agonist Formulations and Methods of Using the Same TEIKOKU PHARMA USA, INC. 2018-10-11 US disclosed
EP-3160965-A1 3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2017-05-03 EP disclosed
WO-2007076875-A2 COMPOUNDS ACTING ON THE SEROTONIN TRANSPORTER AARHUS UNIVERSITET (DK) 2007-07-12 WO disclosed
WO-2006125596-A1 ORGANIC COMPOUNDS FOR THE TREATMENT OF IMFLAMMATORY OR ALLERIC CONDITIONS NOVARTIS AG (CH) 2006-11-30 WO disclosed
WO-2006125616-A2 PYRIMIDINE-BASED CDK INHIBITORS FOR TREATING PAIN INGENIUM PHARMACEUTICALS AG (DE) 2006-11-30 WO disclosed
WO-2006120178-A1 NEW HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES NOVO NORDISK A/S (DK) 2006-11-16 WO disclosed
WO-2006108572-A2 NOVEL CRYSTALLINE PHARMACEUTICAL PRODUCT GLAXO GROUP LIMITED (GB) 2006-10-19 WO disclosed
WO-2006087140-A1 NOVELL PROCESSES FOR THE PREPARATION OF A BENZOFURAN ARPIDA AG (CH) 2006-08-24 WO disclosed
WO-2006069656-A1 FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2006-07-06 WO disclosed
WO-2006067073-A1 COATING COMPOSITIONS FOR MARKING SUBSTRATES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2006-06-29 WO disclosed
WO-2006063763-A1 PYRROLE DERIVATIVES HAVING CRTH2 RECEPTOR ANTAGONIST ACTIVITY NOVARTIS AG (CH) 2006-06-22 WO disclosed
EP-1268581-B1 STABLE INITIATOR SYSTEM JOHNSON & JOHNSON VISION CARE (US) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125390-A1 SOLID FORMS OF MACROCYCLIC COMPOUNDS, SALTS AND FORMULATIONS THEREOF, AND METHODS OF PREPARING AND USING THE SAME FDPS, PCTP, MTTP HPGD 3517/4885HSD17B10 1238/4885CYP1A2 3167/4885
US-20180289640-A1 Topical Sphingosine-1-Phosphate Receptor Agonist Formulations and Methods of Using the Same S1PR1, S1PR4, S1PR2 HPGD 3592/4885HSD17B10 3472/4885CYP1A2 4064/4885
US-10188616-B2 Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same S1PR1, S1PR4, S1PR2 HPGD 3592/4885HSD17B10 3472/4885CYP1A2 4064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.