Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Spermidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.88 |
| ▸ | CA6 | P23280 | 5/20 | 0.88 |
| ▸ | CA7 | P43166 | 5/20 | 0.88 |
| ▸ | CA9 | Q16790 | 5/20 | 0.88 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.88 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.88 |
| ▸ | CA2 | P00918 | 4/20 | 0.88 |
| ▸ | CA4 | P22748 | 4/20 | 0.88 |
| ▸ | CA5A | P35218 | 4/20 | 0.88 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.88 |
| ▸ | CA3 | P07451 | 3/20 | 0.88 |
| ▸ | F13A1 | P00488 | 2/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | THPO | P40225 | 2/20 | 0.88 |
| ▸ | CA1 | P00915 | 2/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.88 |
| ▸ | PKM | P14618 | 1/20 | 0.88 |
| ▸ | TSHR | P16473 | 1/20 | 0.88 |
| ▸ | MTOR | P42345 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spermine SCHEMBL5387663 | 0.97 | CA12 (0.87) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL2514297 | 0.94 | CA12 (0.88) | CA12CA6CA7CA9CA14 | |
| Spermine SCHEMBL431884 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL3175232 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL3165201 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermine SCHEMBL6466326 | 0.94 | CA12 (0.93) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL8073115 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL15618 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL6253721 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermine SCHEMBL288605 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118620820-A | Method for extracting plant single cell nucleus and special kit thereof | 中国农业科学院生物技术研究所 | 2024-09-10 | — | — | CN | disclosed |
| WO-2024121732-A1 | COMPOSITION FOR THE MODIFIED RELEASE OF BIOLOGICAL POLYAMINES, IN PARTICULAR SPERMIDINE | GIULIANI S.P.A. (IT) | 2024-06-13 | — | — | WO | disclosed |
| WO-2022063979-A1 | SPERMIDINE IN TREATMENT OF DYSBIOSIS AND ASSOCIATED INFLAMMATORY CONDITIONS OF THE GASTROINTESTINAL TRACT | Universität Zürich (CH) | 2022-03-31 | — | — | WO | disclosed |
| CN-108684668-B | Application of spermidine salt in preventing and treating pine wood nematode disease | 华南农业大学 | 2020-10-23 | — | — | CN | disclosed |
| US-7232846-B2 | Amines as anti-alcoholism agents | GARBIL PHARMA INVESTIGACION CHILE LTDA. | 2007-06-19 | — | — | US | disclosed |
| US-20040242701-A1 | Amines as ant-alcoholism agents | GARBIL PHARMA INVESTIGACION CHILE LTDA. (CL) | 2004-12-02 | — | — | US | disclosed |
| EP-1437133-A1 | AMINES WITH ANTIALCOHOLIC AGENTS | Garbil Pharma Investigacion Chile Ltda. (CL) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003026634-A1 | AMINES WITH ANTIALCOHOLIC AGENTS | GARBIL PHARMA INVESTIGACION CHILE LTDA. (CL) | 2003-04-03 | — | — | WO | disclosed |