Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Spermidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.88 |
| ▸ | CA6 | P23280 | 5/20 | 0.88 |
| ▸ | CA7 | P43166 | 5/20 | 0.88 |
| ▸ | CA9 | Q16790 | 5/20 | 0.88 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.88 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.88 |
| ▸ | CA2 | P00918 | 4/20 | 0.88 |
| ▸ | CA4 | P22748 | 4/20 | 0.88 |
| ▸ | CA5A | P35218 | 4/20 | 0.88 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.88 |
| ▸ | CA3 | P07451 | 3/20 | 0.88 |
| ▸ | F13A1 | P00488 | 2/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | THPO | P40225 | 2/20 | 0.88 |
| ▸ | CA1 | P00915 | 2/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.88 |
| ▸ | PKM | P14618 | 1/20 | 0.88 |
| ▸ | TSHR | P16473 | 1/20 | 0.88 |
| ▸ | MTOR | P42345 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spermidine SCHEMBL5384705 | 0.94 | CA12 (0.88) | CA12CA6CA7CA9CA14 | |
| Spermine SCHEMBL288605 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL3165201 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL288987 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL3175232 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL6253721 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermine SCHEMBL431884 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL8073115 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermidine SCHEMBL15618 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Spermine SCHEMBL5802297 | 0.94 | CA12 (1.00) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10138462-B2 | Natural killer cell lines and methods of use | NANTKWEST, INC. (US) | 2018-11-27 | — | — | US | disclosed |
| EP-2661498-B1 | FIBER SELECTIVE PROMOTERS | BAYER CROPSCIENCE NV (BE) | 2016-11-30 | — | — | EP | disclosed |
| US-9243260-B2 | Fiber selective promoters | BAYER CROPSCIENCE NV (BE) | 2016-01-26 | — | — | US | disclosed |
| CN-103328635-B | Fiber-selective promoters | BAYER CROPSCIENCE N.V. (BE) | 2015-11-25 | — | — | CN | disclosed |
| US-20140099714-A1 | NATURAL KILLER CELL LINES AND METHODS OF USE | CONKWEST, INC. (US) | 2014-04-10 | — | — | US | disclosed |
| EP-2661498-A1 | FIBER SELECTIVE PROMOTERS | Bayer CropScience NV (BE) | 2013-11-13 | — | — | EP | disclosed |
| US-20130276170-A1 | FIBER SELECTIVE PROMOTERS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 2013-10-17 | — | — | US | disclosed |
| CN-103328635-A | Fiber-selective promoters | BAYER CROPSCIENCE NV | 2013-09-25 | — | — | CN | disclosed |
| WO-2012093032-A1 | FIBER SELECTIVE PROMOTERS | BAYER CROPSCIENCE N.V. (BE) | 2012-07-12 | — | — | WO | disclosed |
| US-8034332-B2 | Vectors for transfection mammal cells; purging cells in sample | CONKWEST, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-6617153-B2 | Portable magneto-mechanical delivery device and method for delivery of reactive substances | KUEHNLE ADELHEID (US) | 2003-09-09 | — | — | US | disclosed |
| US-20020127722-A1 | Portable magneto-mechanical delivery device and method for delivery of reactive substances | KUEHNLE ADELHEID (US) | 2002-09-12 | — | — | US | disclosed |
| US-20020098359-A1 | Method and apparatus for manufacture of magnetizable microparticles | KUEHNLE MANFRED R (US) | 2002-07-25 | — | — | US | disclosed |
| WO-2002046358-A1 | PORTABLE MAGNETO-MECHANICAL DELIVERY DEVICE AND METHOD FOR DELIVERY OF REACTIVE SUBSTANCES | KUEHNLE ADELHEID R (US) | 2002-06-13 | — | — | WO | disclosed |
| US-20020068044-A1 | Natural killer cell lines and methods of use | INFINITY SA LLC, AS PURCHASER AGENT | 2002-06-06 | — | — | US | disclosed |
| WO-2001084565-A2 | METHOD AND APPARATUS FOR MANUFACTURE OF MAGNETIZABLE MICROPARTICLES | KUEHNLE MANFRED R (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1007630-A4 | NATURAL KILLER CELL LINES AND METHODS OF USE | KLINGEMANN HANS (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-1007630-A1 | NATURAL KILLER CELL LINES AND METHODS OF USE | Klingemann, Hans (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1998049268-A9 | NATURAL KILLER CELL LINES AND METHODS OF USE | KLINGEMANN HANS (US) | 1999-03-25 | — | — | WO | disclosed |
| WO-1998049268-A1 | NATURAL KILLER CELL LINES AND METHODS OF USE | KLINGEMANN HANS (US) | 1998-11-05 | — | — | WO | disclosed |