SCHEMBL538517

SCHEMBL538517

CCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCOc1ccc2c(c1)C(Br)(c1cccc(F)c1)c1ccccc1-2

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 19/20 0.53
PTPN11 Q06124 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31193446 0.97 PDK2 (0.56) PDK2PTPN11
SCHEMBL21464021 0.93 PDK2 (0.52) PDK2PTPN11
SCHEMBL15470845 0.89 PDK2 (0.46) PDK2
SCHEMBL10251466 0.87 PDK2 (0.54) PDK2PTPN11
SCHEMBL15608159 0.86 PDK2 (0.59) PDK2PTPN11
SCHEMBL28501701 0.81 PDK2 (0.42) PDK2PTPN11
SCHEMBL538516 0.80 PDK2 (0.56) PDK2PTPN11
SCHEMBL23094042 0.78 PDK2 (0.50) PDK2PTPN11
SCHEMBL539157 0.75 PDK2 (0.50) PDK2PTPN11
SCHEMBL31003500 0.74 GPR3 (0.41) PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12454526-B2 Method for producing pyrrole-imidazole (poly)amide KANEKA CORPORATION (JP) 2025-10-28 US claimed
US-12351601-B2 Method for producing peptide continuously AJINOMOTO CO., INC. (JP) 2025-07-08 US claimed
US-20220041648-A1 METHOD FOR PRODUCING PEPTIDE CONTINUOUSLY AJINOMOTO CO., INC. (JP) 2022-02-10 US claimed
WO-2020218497-A1 METHOD FOR PRODUCING PEPTIDE CONTINUOUSLY 味の素株式会社 2020-10-29 WO claimed
US-9353147-B2 Method for producing peptide AJINOMOTO CO., INC. (JP) 2016-05-31 US claimed
US-9029504-B2 Fluorene compound AJINOMOTO CO., INC. (JP) 2015-05-12 US claimed
US-20140088291-A1 METHOD FOR PRODUCING PEPTIDE AJINOMOTO CO., INC. (JP) 2014-03-27 US claimed
US-20140046022-A1 FLUORENE COMPOUND AJINOMOTO CO., INC. (JP) 2014-02-13 US claimed
EP-2415744-A1 FLUORENE COMPOUND Ajinomoto Co., Inc. (JP) 2012-02-08 EP claimed
US-20100240867-A1 FLUORENE COMPOUND AJINOMOTO CO. INC. (JP) 2010-09-23 US claimed
US-12351601-B2 Method for producing peptide continuously AJINOMOTO CO., INC. (JP) 2025-07-08 US disclosed
US-11939404-B2 Method for producing cyclized peptide having intramolecular S-S bond AJINOMOTO CO., INC. (JP) 2024-03-26 US disclosed
EP-4011902-A1 METHOD FOR PRODUCING PEPTIDE COMPOUND, REAGENT FOR FORMING PROTECTING GROUP, AND HYDRAZINE DERIVATIVE FUJIFILM Corporation (JP) 2022-06-15 EP disclosed
US-20220041648-A1 METHOD FOR PRODUCING PEPTIDE CONTINUOUSLY AJINOMOTO CO., INC. (JP) 2022-02-10 US disclosed
EP-3882255-A1 METHOD FOR PRODUCING CYCLIZED PEPTIDE HAVING INTRAMOLECULAR S-S BOND AJINOMOTO CO., INC. (JP) 2021-09-22 EP disclosed
US-8569453-B2 Fluorene compound AJINOMOTO CO., INC. (JP) 2013-10-29 US disclosed
EP-2415744-A1 FLUORENE COMPOUND Ajinomoto Co., Inc. (JP) 2012-02-08 EP disclosed
EP-2415744-A1 FLUORENE COMPOUND Ajinomoto Co., Inc. (JP) 2012-02-08 EP disclosed
US-20100240867-A1 FLUORENE COMPOUND AJINOMOTO CO. INC. (JP) 2010-09-23 US disclosed
WO-2010104169-A1 FLUORENE COMPOUND 味の素株式会社 (JP) 2010-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220041648-A1 METHOD FOR PRODUCING PEPTIDE CONTINUOUSLY VIP, NPPA, NGLY1 PDK2 4375/4885PTPN11 2516/4885
US-20140046022-A1 FLUORENE COMPOUND NPPA, FURIN, SFPQ PDK2 3174/4885PTPN11 4108/4885
US-11939404-B2 Method for producing cyclized peptide having intramolecular S-S bond SPPL2B, PTMS, VIP PDK2 4360/4885PTPN11 3171/4885
US-20100240867-A1 FLUORENE COMPOUND NPPA, FURIN, SFPQ PDK2 3174/4885PTPN11 4108/4885
US-20140088291-A1 METHOD FOR PRODUCING PEPTIDE ANPEP, NPPA, LNPEP PDK2 4613/4885PTPN11 2986/4885
US-12351601-B2 Method for producing peptide continuously VIP, NPPA, NGLY1 PDK2 4375/4885PTPN11 2516/4885
US-12454526-B2 Method for producing pyrrole-imidazole (poly)amide DDC, PAM, AADAC PDK2 502/4885PTPN11 4178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.