Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 8/20 | 0.48 |
| ▸ | AKT2 | P31751 | 8/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538528 | 0.81 | ADORA3 (0.40) | AKT1AKT2ADORA3ADORA2AMEN1 | |
| SCHEMBL3706758 | 0.78 | AKT1 (0.46) | AKT1AKT2ADORA2AMEN1NPC1 | |
| SCHEMBL538266 | 0.77 | AKT1 (0.40) | AKT1AKT2ADORA3ADORA2AMEN1 | |
| SCHEMBL539266 | 0.76 | AKT1 (0.41) | AKT1AKT2ADORA3ADORA2AMEN1 | |
| SCHEMBL539284 | 0.76 | MEN1 (0.47) | AKT1AKT2MEN1NPC1NR2F2 | |
| SCHEMBL868863 | 0.75 | AKT1 (0.67) | AKT1AKT2 | |
| SCHEMBL538092 | 0.73 | ADORA1 (0.39) | AKT1AKT2ADORA2AMEN1NPC1 | |
| SCHEMBL538545 | 0.71 | AKT1 (0.38) | AKT1AKT2ADORA3ADORA2AADORA1 | |
| SCHEMBL538122 | 0.71 | ALOX5 (0.43) | AKT1AKT2ADORA3ADORA2AADORA1 | |
| SCHEMBL3710399 | 0.70 | KDM4E (0.49) | AKT1AKT2MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | claimed |