Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.40 |
| ▸ | AKT2 | P31751 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL539266 | 0.85 | AKT1 (0.41) | AKT1AKT2MEN1MAPTKMT2A | |
| SCHEMBL538528 | 0.80 | ADORA3 (0.40) | AKT1AKT2MEN1MAPTKMT2A | |
| SCHEMBL538092 | 0.80 | ADORA1 (0.39) | AKT1AKT2KDM4EMEN1MAPT | |
| SCHEMBL538519 | 0.77 | AKT1 (0.48) | AKT1AKT2MEN1KMT2AADORA3 | |
| SCHEMBL539284 | 0.76 | MEN1 (0.47) | AKT1AKT2MEN1MAPTKMT2A | |
| SCHEMBL538545 | 0.75 | AKT1 (0.38) | AKT1AKT2MAPTADORA3ADORA2A | |
| SCHEMBL867218 | 0.74 | AKT1 (0.59) | AKT1AKT2 | |
| SCHEMBL538827 | 0.73 | ALOX5 (0.45) | KDM4EMEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL3710399 | 0.72 | KDM4E (0.49) | AKT1AKT2KDM4EMEN1MAPT | |
| SCHEMBL19322172 | 0.71 | RAB9A (0.56) | KDM4EMEN1MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | claimed |