Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.51 |
| ▸ | THRA | P10827 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388297 | 1.00 | THRB (0.51) | THRBTHRALMNAMAPTKMT2A | |
| SCHEMBL5397857 | 0.85 | THRA (0.71) | THRBTHRALMNAMAPTKMT2A | |
| SCHEMBL6917732 | 0.85 | THRA (0.71) | THRBTHRALMNAMAPTKMT2A | |
| SCHEMBL5388467 | 0.83 | THRB (0.72) | THRBTHRA | |
| SCHEMBL5858465 | 0.83 | CRHBP (0.41) | THRBTHRAMAPTRAB9ANPC1 | |
| SCHEMBL5381972 | 0.79 | MTNR1B (0.50) | THRBTHRAMAPTKMT2AMEN1 | |
| SCHEMBL5391707 | 0.79 | THRA (0.52) | THRBTHRALMNACYP1A2 | |
| SCHEMBL5391712 | 0.79 | THRA (0.52) | THRBTHRALMNACYP1A2 | |
| SCHEMBL5386428 | 0.78 | KMT2A (0.47) | THRBTHRAMAPTKMT2AMEN1 | |
| SCHEMBL7071559 | 0.76 | LMNA (0.76) | THRBLMNAMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199265-B2 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones | KARO BIO AB (SE) | 2007-04-03 | — | — | US | disclosed |
| EP-1296936-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098256-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2001-12-27 | — | — | WO | disclosed |