SCHEMBL5388688

SCHEMBL5388688

COc1ccc(C=Nc2cccc([N+](=O)[O-])c2)c2ccccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.62
▸ KMT2A Q03164 6/20 0.62
▸ ALDH1A1 P00352 8/20 0.50
▸ MAPT P10636 8/20 0.50
▸ KDM4E B2RXH2 5/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ HPGD P15428 2/20 0.48
▸ GAA P10253 3/20 0.44
▸ CYP1A2 P05177 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ PKM P14618 1/20 0.44
▸ ALOX12 P18054 1/20 0.44
▸ CYP2C19 P33261 1/20 0.44
▸ MPI P34949 1/20 0.44
▸ MGAM O43451 1/20 0.44
▸ SI P14410 1/20 0.44
▸ MGAM2 Q2M2H8 1/20 0.44
▸ HTT P42858 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ TDP1 Q9NUW8 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30865010 1.00 MEN1 (0.62) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL5388684 1.00 MEN1 (0.62) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL6568868 0.77 GAA (0.45) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL6568870 0.77 GAA (0.45) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL14159163 0.74 ALDH1A1 (0.48) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL12416661 0.74 NFE2L2 (0.63) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL7269602 0.73 MEN1 (0.51) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL7269599 0.73 MEN1 (0.51) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL28964169 0.72 MEN1 (0.67) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL12416609 0.72 MEN1 (0.67) MEN1KMT2AALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092078-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-04-02 — — US claimed
WO-2024064080-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-03-28 — — WO claimed
US-20260092078-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-04-02 — — US disclosed
WO-2024064080-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-03-28 — — WO disclosed
JP-2007314486-A STAT6 ACTIVATION INHIBITOR CONTAINING NAPHTHALENE DERIVATIVE AS ACTIVE INGREDIENT KOWA CO 2007-12-06 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092078-A1 STAT6 DEGRADERS AND USES THEREOF STAT6, ADRM1, MDM2 MEN1 4343/4885KMT2A 521/4885ALDH1A1 3021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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