Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20468858 | 0.83 | ALDH1A1 (0.50) | CHRNB2CHRNA4ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL20798113 | 0.83 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3KCNJ1 | |
| SCHEMBL30057551 | 0.83 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3KCNJ1 | |
| SCHEMBL20469182 | 0.81 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2D6CYP3A4USP2 | |
| SCHEMBL1556835 | 0.81 | CHRNB4 (0.61) | CHRNB2CHRNA4ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL1426895 | 0.81 | ALDH1A1 (0.50) | CHRNB2CHRNA4ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL1426554 | 0.80 | USP2 (0.56) | ALDH1A1CYP1A2CYP2D6CYP3A4USP2 | |
| SCHEMBL1556717 | 0.80 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6CYP3A4USP2 | |
| SCHEMBL20468861 | 0.79 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2D6CYP3A4USP2 | |
| SCHEMBL1556724 | 0.79 | CHRNB2 (0.61) | CHRNB2CHRNA4ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291731-B2 | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof | TARGACEPT, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| US-20050272739-A1 | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof | BHATTI BALWINDER S | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272739-A1 | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof | TNNC1, ACHE, CHRNA6 | CHRNB2 14/4885CHRNA4 9/4885ALDH1A1 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.