Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LIG1 | P18858 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426911 | 0.73 | SLC6A9 (0.45) | HSD11B1SLC6A9OPRM1KCNH2GRIN2B | |
| SCHEMBL23780914 | 0.71 | LMNA (0.49) | POLBALDH1A1 | |
| SCHEMBL11594047 | 0.65 | CCR1 (0.41) | HSD11B1OPRM1KCNH2TACR1ALDH1A1 | |
| SCHEMBL10676298 | 0.63 | MEN1 (0.63) | HSD11B1MAOBMAOAALDH1A1LIG1 | |
| SCHEMBL61987 | 0.63 | ALDH1A1 (0.55) | POLBALDH1A1 | |
| SCHEMBL2761726 | 0.61 | GAA (0.40) | ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11594099 | 0.61 | HSD11B1 (0.33) | HSD11B1SLC6A9OPRM1 | |
| SCHEMBL5768239 | 0.60 | CYP2C9 (0.50) | HSD11B1OPRM1CYP3A4CYP2C19 | |
| SCHEMBL8005872 | 0.60 | MAOB (0.39) | HSD11B1MAOBMAOA | |
| SCHEMBL613615 | 0.60 | OPRM1 (0.45) | POLBOPRM1KCNH2TACR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414332-A1 | ACRYLAMIDE COMPOUNDS AND THE USE THEREOF | Shionogi & Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114181-A1 | ACRYLAMIDE COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2010-10-07 | — | — | WO | disclosed |