Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.76 |
| ▸ | MEN1 | O00255 | 10/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.76 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.76 |
| ▸ | AKT1 | P31749 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 4/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.65 |
| ▸ | CTSB | P07858 | 1/20 | 0.65 |
| ▸ | ELANE | P08246 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401641 | 0.87 | ALDH1A1 (0.82) | ALDH1A1ALOX12TDP1KMT2AMEN1 | |
| SCHEMBL13212128 | 0.83 | MEN1 (1.00) | ALDH1A1ALOX12TDP1KMT2AMEN1 | |
| SCHEMBL287025 | 0.82 | AKT1 (1.00) | ALDH1A1KMT2AMEN1MAPTAKT1 | |
| SCHEMBL11893078 | 0.81 | AKT1 (0.80) | ALDH1A1KMT2AMEN1AKT1PKM | |
| SCHEMBL13212124 | 0.79 | KMT2A (0.80) | ALDH1A1ALOX12TDP1KMT2AMEN1 | |
| SCHEMBL5407138 | 0.79 | MEN1 (1.00) | ALDH1A1KMT2AMEN1AKT1PKM | |
| SCHEMBL15840511 | 0.78 | KMT2A (1.00) | ALDH1A1ALOX12TDP1KMT2AMEN1 | |
| SCHEMBL12173925 | 0.78 | ALDH1A1 (0.64) | ALDH1A1ALOX12TDP1KMT2AMEN1 | |
| SCHEMBL31058614 | 0.78 | KMT2A (0.81) | ALDH1A1ALOX12TDP1KMT2AMEN1 | |
| SCHEMBL15840649 | 0.78 | ALDH1A1 (0.65) | ALDH1A1ALOX12TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066614-A1 | Ihibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB | 2007-03-22 | — | — | US | disclosed |
| US-7173030-B2 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB (SE) | 2007-02-06 | — | — | US | disclosed |
| US-20050009821-A1 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009821-A1 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | HSD11B1, HSD17B1, HSD11B2 | ALDH1A1 53/4885ALOX12 366/4885TDP1 926/4885 |
| US-20070066614-A1 | Ihibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | HSD11B1, HSD17B1, HSD17B11 | ALDH1A1 36/4885ALOX12 736/4885TDP1 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.