Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 4/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5419589 | 0.89 | PDE1A (0.52) | PDE1APDE1BPDE1CMEN1KMT2A | |
| SCHEMBL5407727 | 0.87 | PDE1A (0.45) | PDE1APDE1BPDE1CALDH1A1SMN1; SMN2 | |
| SCHEMBL5402553 | 0.85 | PDE1A (0.41) | PDE1APDE1BPDE1CALDH1A1MEN1 | |
| SCHEMBL5393375 | 0.85 | KMT2A (0.46) | PDE1APDE1BPDE1CALDH1A1SMN1; SMN2 | |
| SCHEMBL5402794 | 0.84 | PDE1B (0.41) | PDE1APDE1BPDE1CALDH1A1PDE2A | |
| SCHEMBL5395371 | 0.84 | SLC16A1 (0.52) | PDE1APDE1BPDE1CALDH1A1SMN1; SMN2 | |
| SCHEMBL5393363 | 0.83 | PDE1A (0.40) | PDE1APDE1BPDE1CALDH1A1PDE2A | |
| SCHEMBL5400574 | 0.83 | ADORA2B (0.48) | PDE1APDE1BPDE1CALDH1A1SMN1; SMN2 | |
| SCHEMBL5398896 | 0.83 | PCSK9 (0.43) | PDE1APDE1BPDE1CHIF1A | |
| SCHEMBL5411300 | 0.82 | PDE1A (0.41) | PDE1APDE1BPDE1CALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | DPYD, HPGDS, PGC | PDE1A 4056/4885PDE1B 4206/4885PDE1C 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.