Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A1 | P53985 | 3/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | RAD52 | P43351 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5402814 | 0.89 | SLC16A1 (0.44) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5395453 | 0.87 | SLC16A1 (0.44) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5395371 | 0.87 | SLC16A1 (0.52) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5399687 | 0.86 | SLC16A1 (0.39) | SLC16A1KMT2ANPBWR1LMNA | |
| SCHEMBL5404441 | 0.85 | SLC16A1 (0.42) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5395420 | 0.84 | SLC16A1 (0.43) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5400442 | 0.84 | ALDH1A1 (0.44) | SLC16A1SMN1; SMN2KMT2AHTTL3MBTL1 | |
| SCHEMBL5409782 | 0.84 | SLC16A1 (0.41) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5408067 | 0.84 | SLC16A1 (0.41) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5411276 | 0.83 | SLC16A1 (0.41) | SLC16A1PDE5APDE3BPDE3ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | DPYD, HPGDS, PGC | SLC16A1 4140/4885TOP2A 1278/4885PDE5A 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.