Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 8/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP2 | P42575 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.47 |
| ▸ | MAFG | O15525 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037323 | 0.92 | TDP1 (0.51) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL7577396 | 0.92 | TDP1 (0.64) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL29946177 | 0.89 | TDP1 (0.53) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL29802482 | 0.89 | TDP1 (0.53) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL6534725 | 0.88 | CASP3 (0.55) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL8219653 | 0.86 | CASP3 (0.53) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL31378057 | 0.86 | TDP1 (0.69) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL31248180 | 0.86 | TDP1 (0.69) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL31378143 | 0.86 | TDP1 (0.68) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL30313496 | 0.85 | CASP3 (0.47) | FOLH1CASP3CASP1CASP2CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247438-B1 | Methods of identifying agents which enhance caspase activity | DANA-FARBER CANCER INSTITUTE (US) | 2007-07-24 | — | — | US | disclosed |