SCHEMBL7071083

SCHEMBL7071083

COc1cncc(C(C)=CCC(C)O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MKNK2 Q9HBH9 2/20 0.35
ROCK2 O75116 1/20 0.35
MAP4K4 O95819 1/20 0.35
PRKACA P17612 1/20 0.35
ROCK1 Q13464 1/20 0.35
DYRK1A Q13627 1/20 0.35
NTRK3 Q16288 1/20 0.35
PKN2 Q16513 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35
STK17A Q9UEE5 1/20 0.35
MKNK1 Q9BUB5 1/20 0.35
CYP3A4 P08684 6/20 0.33
CYP2D6 P10635 4/20 0.33
SLC6A2 P23975 4/20 0.33
SLC6A4 P31645 4/20 0.33
SLC6A3 Q01959 4/20 0.33
KCNH2 Q12809 1/20 0.33
CYP11B1 P15538 3/20 0.33
CYP11B2 P19099 3/20 0.33
CYP1A2 P05177 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL365734 0.87 MKNK2 (0.37) MKNK2ROCK2MAP4K4PRKACAROCK1
SCHEMBL5406058 0.78 MKNK2 (0.38) MKNK2ROCK2MAP4K4PRKACAROCK1
SCHEMBL3956347 0.75 MKNK1 (0.33) MKNK2MKNK1
SCHEMBL1691836 0.74 CHRNB2 (0.41) CYP11B1CYP11B2
SCHEMBL4242135 0.73 CHRNB2 (0.36) CYP11B1CYP11B2
SCHEMBL3017873 0.72 CHRNB2 (0.53) MKNK2ROCK2MAP4K4PRKACAROCK1
SCHEMBL3017868 0.72 CHRNB2 (0.53) MKNK2ROCK2MAP4K4PRKACAROCK1
SCHEMBL5196858 0.69 LTA4H (0.40) KCNH2
SCHEMBL3209723 0.69 CYP11B1 (0.58) MKNK2MAP4K4MKNK1CYP3A4CYP11B1
SCHEMBL5196868 0.68 LNPEP (0.37) MAP4K4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1317267-A2 COMPOSITIONS CONTAINING DIACYLTARTARIC SALTS OF (E)-METANICOTINE Targacept, Inc. (US) 2003-06-11 EP disclosed
EP-1311265-A2 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS Targacept, Inc. (US) 2003-05-21 EP disclosed
EP-1185514-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE Targacept, Inc. (US) 2002-03-13 EP disclosed
WO-2002005801-A2 COMPOSITIONS CONTAINING DIACYLTARTARIC SALTS OF (E)-METANICOTINE TARGACEPT, INC. (US) 2002-01-24 WO disclosed
WO-2002005798-A2 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS TARGACEPT, INC. (US) 2002-01-24 WO disclosed
WO-2000075110-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE TARGACEPT, INC. (US) 2000-12-14 WO disclosed