Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28267072 | 1.00 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL27844339 | 0.97 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3345299 | 0.86 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL2520407 | 0.86 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL8893418 | 0.86 | LMNA (0.67) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL28115742 | 0.86 | CYP3A4 (0.77) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL2162751 | 0.85 | LMNA (0.52) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL8056351 | 0.85 | — | — | |
| Choline SCHEMBL6706932 | 0.84 | MEN1 (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1302619 | 0.84 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 253 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596134-B1 | DEEP EUTECTIC SOLVENT COMPOSITIONS | SHPP GLOBAL TECH BV (NL) | 2023-10-18 | — | — | EP | claimed |
| US-11530317-B2 | Deep eutectic solvent compositions | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2022-12-20 | — | — | US | claimed |
| CN-113358528-B | Method for detecting acetylcholinesterase and inhibitor thereof based on pendant drop method | 山东大学 | 2022-06-17 | — | — | CN | claimed |
| CN-111384360-B | Metal ion battery | 财团法人工业技术研究院 | 2022-02-22 | — | — | CN | claimed |
| CN-111384432-B | Metal ion battery | 财团法人工业技术研究院 | 2022-02-01 | — | — | CN | claimed |
| CN-113358528-A | Method for detecting acetylcholinesterase and inhibitor thereof based on pendant drop method | 山东大学 | 2021-09-07 | — | — | CN | claimed |
| US-11071795-B2 | Indicating devices based on etching of metals | JP LABORATORIES INC. (US) | 2021-07-27 | — | — | US | claimed |
| CN-112961027-A | Insoluble copper complex catalyst for catalyzing hydrochlorination of acetylene and preparation method and application thereof | 石河子大学 | 2021-06-15 | — | — | CN | claimed |
| CN-107799724-B | Electrode, method for manufacturing same, and metal-ion battery comprising same | 财团法人工业技术研究院 | 2020-10-23 | — | — | CN | claimed |
| CN-111675640-A | Method for separating and preparing high-purity zeaxanthin | 中国科学院兰州化学物理研究所 | 2020-09-18 | — | — | CN | claimed |
| EP-2136636-B1 | PEST ATTRACTANT | ACTIVETRAD PROPRIETARY LTD (ZA) | 2011-11-02 | — | — | EP | claimed |
| US-20100119473-A1 | INSECT ATTRACTANT | ACTIVETRAD (PROPRIETARY) LIMITED (ZA) | 2010-05-13 | — | — | US | claimed |
| EP-2136636-A1 | PEST ATTRACTANT | Activetrad (Proprietary) Limited (ZA) | 2009-12-30 | — | — | EP | claimed |
| EP-1317294-B2 | ABSORBABLE ADHESIVE COMPOSITIONS | CLOSURE MEDICAL CORP (US) | 2009-09-02 | — | — | EP | claimed |
| WO-2008110984-A1 | PEST ATTRACTANT | ACTIVETRAD (PROPRIETARY) LIMITED (ZA) | 2008-09-18 | — | — | WO | claimed |
| EP-1317294-B1 | ABSORBABLE ADHESIVE COMPOSITIONS | CLOSURE MEDICAL CORP (US) | 2005-03-16 | — | — | EP | claimed |
| US-6620846-B1 | Containing biocompatible alkyl ester cyanoacrylate monomer and quaternary amine polymerization initiator | CLOSURE MEDICAL CORPORATION | 2003-09-16 | — | — | US | claimed |
| EP-1317294-A1 | ABSORBABLE ADHESIVE COMPOSITIONS | Closure Medical Corporation (US) | 2003-06-11 | — | — | EP | claimed |
| US-6395077-B1 | INKS WITH BENZOYLBENZOIC ACID AND COLORS | XEROX CORPORATION | 2002-05-28 | — | — | US | claimed |
| WO-2002009785-A1 | ABSORBABLE ADHESIVE COMPOSITIONS | CLOSURE MEDICAL CORPORATION (US) | 2002-02-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530317-B2 | Deep eutectic solvent compositions | YAP1, MYB, PRDX6 | LMNA 4565/4885MEN1 4529/4885KMT2A 2394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.