Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15853291 | 0.86 | MAPT (0.45) | CNR2CNR1MAPTNCEH1TLR8 | |
| SCHEMBL23775992 | 0.83 | GPR3 (0.42) | CNR2CNR1MAPTNCEH1TSHR | |
| SCHEMBL5502423 | 0.80 | CNR2 (0.35) | CNR2CNR1MAPTTLR8KDM4E | |
| SCHEMBL2009887 | 0.80 | CNR2 (0.39) | CNR2CNR1MAPTMCL1KDM4E | |
| SCHEMBL299862 | 0.78 | MAPT (0.53) | MAPTNCEH1TLR8KDM4EHSD17B10 | |
| SCHEMBL10058007 | 0.77 | L3MBTL1 (0.39) | CNR2CNR1MAPTTLR8KDM4E | |
| SCHEMBL10058033 | 0.77 | L3MBTL1 (0.39) | CNR2CNR1MAPTTLR8KDM4E | |
| SCHEMBL27804756 | 0.77 | LIPG (0.40) | CNR2CNR1MAPTTLR8KDM4E | |
| SCHEMBL16267023 | 0.76 | MAPT (0.55) | MAPTTLR8KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5116260 | 0.76 | MAPT (0.55) | MAPTTLR8KDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373605-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN | UNIV DUNDEE (GB) | 2014-08-13 | — | — | EP | disclosed |
| WO-2007028145-A2 | AGENTS AND METHODS FOR REDUCING PROTEIN TYROSINE PHOSPHATASE 1B ACTIVITY IN THE CENTRAL NERVOUS SYSTEM | DARA BIOSCIENCES, INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-7163952-B2 | Azole compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2007-01-16 | — | — | US | disclosed |
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-06-08 | — | — | US | disclosed |
| EP-1553091-A1 | HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-07-13 | — | — | EP | disclosed |
| US-20050065196-A1 | Azole compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2005-03-24 | — | — | US | disclosed |
| EP-1452530-A1 | AZOLE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2004-09-01 | — | — | EP | disclosed |
| US-6498182-B2 | BENZO(G)INDOLE -2,5(3H)-DIONE AND -2-ONE DERIVATIVE ANTIDIABETIC AGENTS | BIOVITRUM AB (SE) | 2002-12-24 | — | — | US | disclosed |
| US-20020115663-A1 | Novel compounds | BIOVITRUM AB (SE) | 2002-08-22 | — | — | US | disclosed |
| US-20020061921-A1 | Novel compounds | BIOVITRUM AB (SE) | 2002-05-23 | — | — | US | disclosed |
| WO-2002026707-A1 | NOVEL COMPOUNDS | BIOVITRUM AB (SE) | 2002-04-04 | — | — | WO | disclosed |
| WO-2002026743-A1 | NOVEL PYRIDAZINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BIOVITRUM AB (SE) | 2002-04-04 | — | — | WO | disclosed |
| EP-1077970-A1 | 11-ARYL-BENZO(B)NAPHTHO(2,3-D)FURANS AND 11-ARYL-BENZO(B)NAPHTHO(2,3-D)THIOPHENES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6110962-A | FOR TREATING INSULIN RESISTANCE, TYPE II DIABETES, HYPERGLYCEMIA, MODULATING INSULIN LEVELS IN MAMMALS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | PTPN11, PTPN1, PTPN3 | CNR2 428/4885CNR1 239/4885MAPT 4785/4885 |
| US-20020115663-A1 | Novel compounds | SLC5A2, SLC5A1, GPR119 | CNR2 81/4885CNR1 185/4885MAPT 3157/4885 |
| US-20050065196-A1 | Azole compound and medicinal use thereof | PTPN7, PTPN1, PTPN5 | CNR2 384/4885CNR1 185/4885MAPT 4536/4885 |
| US-20020061921-A1 | Novel compounds | GPR119, IAPP, GLP1R | CNR2 657/4885CNR1 575/4885MAPT 4596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.