Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.64 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.56 |
| ▸ | CASR | P41180 | 1/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | CTSA | P10619 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5408556 | 0.91 | UTS2R (0.57) | ROCK2ROCK1UTS2RCASRCTSA | |
| SCHEMBL9384225 | 0.87 | FPR2 (0.63) | ROCK2ROCK1ITGB3ITGA2BMEN1 | |
| SCHEMBL31527875 | 0.83 | EEF2K (0.58) | ROCK2ROCK1ITGB3ITGA2BHSD17B10 | |
| SCHEMBL5403645 | 0.82 | ROCK2 (0.54) | ROCK2ROCK1UTS2RCASRITGB3 | |
| SCHEMBL5424871 | 0.79 | UTS2R (0.62) | ROCK2ROCK1UTS2RCASRMEN1 | |
| SCHEMBL5400966 | 0.79 | ROCK2 (0.51) | ROCK2ROCK1UTS2RCASRHSD17B10 | |
| SCHEMBL5404142 | 0.78 | ADAMTS4 (0.56) | ROCK2ROCK1UTS2RCASRPTPN1 | |
| SCHEMBL5404149 | 0.78 | ADAMTS4 (0.56) | ROCK2ROCK1UTS2RCASRPTPN1 | |
| SCHEMBL14822987 | 0.78 | PKM (0.54) | ROCK2ROCK1UTS2RCASRPTPN1 | |
| SCHEMBL9304020 | 0.78 | KMT2A (0.57) | ITGB3ITGA2BCTSAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202269-B2 | GlyT2 modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| US-20050119245-A1 | GlyT2 modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-06-02 | — | — | US | disclosed |
| WO-2005044810-A1 | GLYT2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119245-A1 | GlyT2 modulators | GLRB, GLRA1, GLRA2 | ROCK2 3542/4885ROCK1 3815/4885UTS2R 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.