Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5410525 | 0.90 | HTR2A (0.36) | HTR2AGPBAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL5410248 | 0.86 | HTR1A (0.38) | GPBAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5421523 | 0.86 | HTR1A (0.38) | GPBAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5410252 | 0.86 | HTR1A (0.38) | GPBAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL14594175 | 0.85 | KDM4E (0.42) | HTR2AGPBAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL5596599 | 0.82 | GPBAR1 (0.36) | GPBAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5421579 | 0.80 | GPBAR1 (0.36) | GPBAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5413655 | 0.80 | DRD2 (0.36) | GPBAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5415719 | 0.79 | ROCK2 (0.36) | GPBAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5407101 | 0.79 | VCP (0.37) | GPBAR1OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160894-B2 | Antagonist of phosphorylation of myosin regulatory light chain, enzyme inhibitors; therapeutic treatment of glaucoma, bronchial asthma, chronic obstructive pulmonary disease, nervous system disorders; 4-(2,3-dihydro-1,5-diazaphenalen-1-yl)cyclohexylamine | ASAHI KASEI PHARMA CORPORATION (JP) | 2007-01-09 | — | — | US | claimed |
| US-20050096310-A1 | Tricyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2005-05-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096310-A1 | Tricyclic compound | MYLK3, CSNK1A1L, MYLK | HTR2A 1671/4885GPBAR1 2851/4885OPRM1 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.