Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.44 |
| ▸ | CHRNG | P07510 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24114777 | 0.87 | ALDH1A1 (0.56) | LMNAGPR119GAAKMT2AL3MBTL1 | |
| SCHEMBL30148091 | 0.87 | ALDH1A1 (0.56) | LMNAGPR119GAAKMT2AL3MBTL1 | |
| SCHEMBL23992271 | 0.87 | ALDH1A1 (0.56) | LMNAGPR119GAAKMT2AL3MBTL1 | |
| SCHEMBL30487081 | 0.86 | LMNA (0.59) | LMNAGAAKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL20164005 | 0.86 | LMNA (0.59) | LMNAGAAKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8575615 | 0.86 | LMNA (0.59) | LMNAGAAKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL30675171 | 0.83 | GPR119 (0.53) | LMNAGPR119GAAKMT2AL3MBTL1 | |
| SCHEMBL27703992 | 0.83 | GPR119 (0.53) | LMNAGPR119GAAKMT2AL3MBTL1 | |
| SCHEMBL28371859 | 0.79 | GPR119 (0.46) | LMNAGPR119ALDH1A1CHRNA7CHRNB2 | |
| SCHEMBL30675206 | 0.79 | GPR119 (0.46) | LMNAGPR119KMT2AALDH1A1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161614-A1 | Pyridylether derivatives, their preparation and use | PETERS DAN | 2007-07-12 | — | — | US | disclosed |
| US-7202237-B2 | Pyridylether derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 2007-04-10 | — | — | US | disclosed |
| US-20040242558-A1 | Pyridylether derivatives, their preparation and use | NEUROSEARCH A/S | 2004-12-02 | — | — | US | disclosed |
| US-6756386-B1 | SUCH AS 1-METHYL-3-OXY-(5-CHLORO-3-PYRIDYL)-PIPERIDINE; CHOLINERGIC SYSTEM OF CENTRAL NERVOUS SYSTEM; PAIN, INFLAMMATION | NEUROSEARCH A/S (DK) | 2004-06-29 | — | — | US | disclosed |
| EP-1357121-A1 | Azaring-ether deritatives and their use as nicotinic ach receptor modulators | NEUROSEARCH A/S (DK) | 2003-10-29 | — | — | EP | disclosed |
| EP-1034174-B1 | AZARING-ETHER DERIVATIVES AND THEIR USE AS NICOTINIC ACH RECEPTOR MODULATORS | NEUROSEARCH AS (DK) | 2003-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161614-A1 | Pyridylether derivatives, their preparation and use | CHRNA4, CHRNA5, CHRM3 | LMNA 1688/4885GPR119 356/4885GAA 4031/4885 |
| US-20040242558-A1 | Pyridylether derivatives, their preparation and use | CHRNA4, CHRNA5, CHRM3 | LMNA 1688/4885GPR119 356/4885GAA 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.