Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.57 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.51 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30487081 | 1.00 | LMNA (0.59) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL20164005 | 1.00 | LMNA (0.59) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL23992271 | 0.96 | ALDH1A1 (0.56) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL30148091 | 0.96 | ALDH1A1 (0.56) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL24114777 | 0.96 | ALDH1A1 (0.56) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL30675171 | 0.93 | GPR119 (0.53) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL27703992 | 0.93 | GPR119 (0.53) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL5300891 | 0.88 | LMNA (0.67) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL5413682 | 0.86 | LMNA (0.45) | LMNAPRMT5WDR77CHRNB2CHRNA7 | |
| SCHEMBL18701778 | 0.85 | RIPK1 (0.65) | LMNAPRMT5WDR77CHRNB2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111819176-B | 4-azaindole compounds | 百时美施贵宝公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-116390917-A | MRGX2 antagonists | 葛兰素史密斯克莱知识产权发展有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-111699185-B | 6-azaindole compounds | 百时美施贵宝公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-109721620-B | HPK1 inhibitors and uses thereof | 药捷安康(南京)科技股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-111819176-A | 4-azaindole compounds | 百时美施贵宝公司 | 2020-10-23 | — | — | CN | disclosed |
| CN-111699185-A | 6-azaindole compounds | 百时美施贵宝公司 | 2020-09-22 | — | — | CN | disclosed |
| CN-111620865-A | Heterocyclic compound, application thereof and pharmaceutical composition containing same | 苏州信诺维医药科技有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-111620864-A | Heterocyclic compound, application thereof and pharmaceutical composition containing same | 苏州信诺维医药科技有限公司 | 2020-09-04 | — | — | CN | disclosed |
| US-5726182-A | TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |