Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Phenylacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.71 |
| ▸ | CES2 | O00748 | 2/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.64 |
| ▸ | FNTA | P49354 | 1/20 | 0.58 |
| ▸ | FNTB | P49356 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylacetic Acid SCHEMBL11772449 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL1685642 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL78312 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL62440 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL6547052 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL6930085 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL11248694 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL3477184 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL7214226 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB | |
| Phenylacetic Acid SCHEMBL8410214 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119977842-A | Perovskite nano cage material and preparation method thereof | 苏州大学 | 2025-05-13 | — | — | CN | claimed |
| WO-2024149252-A1 | MAGNESIUM PHOSPHATE SUBSTANCE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | 上海石趣医药科技有限公司 | 2024-07-18 | — | — | WO | claimed |
| CN-118146483-A | Flame-retardant low-smoke-toxicity polyurethane foam material and preparation method thereof | 西华大学 | 2024-06-07 | — | — | CN | claimed |
| CN-111115597-B | Preparation method of porous nano hydroxyapatite based on aromatic acid salt | 天津工业大学 | 2023-06-23 | — | — | CN | claimed |
| CN-111484409-B | Preparation method of 2-methyl-4-substituted carbonyloxy-2-butenal | 新发药业有限公司 | 2023-05-05 | — | — | CN | claimed |
| CN-112277496-A | High-performance fountain solution and preparation method thereof | 浙江创思杰印务有限公司 | 2021-01-29 | — | — | CN | claimed |
| CN-111484409-A | Low-cost preparation method of 2-methyl-4-substituted carbonyloxy-2-butenal | 新发药业有限公司 | 2020-08-04 | — | — | CN | claimed |
| CN-111115597-A | Preparation method of porous nano hydroxyapatite based on aromatic acid salt | 天津工业大学 | 2020-05-08 | — | — | CN | claimed |
| EP-1289515-B1 | PHARMACEUTICAL COMPOSITION CONTAINING AT LEAST A POLYMER ASSOCIATED OR CONJUGATED WITH AT LEAST A PHENYLALKYLCARBOXYLIC ACID SALT, CONJUGATE POLYMERS AND USES THEREOF | BIODEX (FR) | 2004-10-13 | — | — | EP | claimed |
| US-20030171333-A1 | Pharmaceutical composition containing at least a polymer combined with or conjugated to at least a phenylalkylcarboxylic acid salt, conjugate polymers and uses thereof | BIODEX (FR) | 2003-09-11 | — | — | US | claimed |
| EP-0885872-B1 | Continuous process for the preparation of aqueous solutions of alkaline salts of arylcetic acids | ATOFINA (FR) | 2001-11-21 | — | — | EP | claimed |
| CN-1203220-A | Process for continuously preparing aryl alkali salt acetate aqueous solution | ATOCHEM ELF SA (FR) | 1998-12-30 | — | — | CN | claimed |
| US-12414986-B2 | Use of glutamine synthetase for treating fatty liver disease | THOERIS GMBH (AT) | 2025-09-16 | — | — | US | disclosed |
| US-12359184-B2 | Use of glutamine synthetase for treating hyperammonemia | THOERIS GMBH (AT) | 2025-07-15 | — | — | US | disclosed |
| US-12338471-B2 | Use of glutamine synthetase for treating hyperammonemia | THOERIS GMBH (AT) | 2025-06-24 | — | — | US | disclosed |
| CN-119977842-A | Perovskite nano cage material and preparation method thereof | 苏州大学 | 2025-05-13 | — | — | CN | disclosed |
| US-4208481-A | BIOSYNTHESIS | E. R. SQUIBB & SONS, INC. (US) | 1980-06-17 | — | — | US | disclosed |
| US-4164445-A | Ethanol as the major source of carbon and energy in penicillin production | E. R. SQUIBB & SONS, INC. (US) | 1979-08-14 | — | — | US | disclosed |
| US-4128572-A | FROM A BENZYL HALIDE AND CARBON MONOXIDE, COBALT HYDROCARBONYL SALT CATALYST | MONTEDISON S.P.A. (IT) | 1978-12-05 | — | — | US | disclosed |
| US-4011180-A | NOVEL COCATALYST SYSTEM FOR TRIMERIZING POLYISOCYANATES | THE UPJOHN COMPANY (US) | 1977-03-08 | — | — | US | disclosed |