Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenylacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.50 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.50 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.71 |
| ▸ | CES2 | O00748 | 2/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | FNTA | P49354 | 1/20 | 0.58 |
| ▸ | FNTB | P49356 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylacetic Acid SCHEMBL7214226 | 1.00 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL11322686 | 0.97 | CES1 (0.68) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL29766219 | 0.97 | CES1 (0.68) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL1685642 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL6930085 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL11772449 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL78312 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL3477184 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL6547052 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 | |
| Phenylacetic Acid SCHEMBL11248694 | 0.95 | CES1 (0.71) | CES1CES2AKR1B1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10923 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-224270252-U | Sodium phenylacetate continuous acidification separation device | HEBEI CHENGXIN Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122037024-A | Preparation method of oil-soluble monodisperse black polymeric microspheres | 深圳市金准生物医学工程有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12522572-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-01-13 | — | — | US | claimed |
| US-12516015-B2 | L-ornithine phenyl acetate and methods of making thereof | AMALIVE LIMITED (GB) | 2026-01-06 | — | — | US | claimed |
| EP-4649317-A2 | METHODS AND COMPOSITIONS FOR SCREENING AND TREATING ALZHEIMER'S DISEASE | Population Bio, Inc. (US) | 2025-11-19 | — | — | EP | claimed |
| US-12414986-B2 | Use of glutamine synthetase for treating fatty liver disease | THOERIS GMBH (AT) | 2025-09-16 | — | — | US | claimed |
| US-20250281517-A1 | SENOLYSIS BY AMMONIA-LOWERING COMPONENT | Taz Inc. (JP) | 2025-09-11 | — | — | US | claimed |
| US-12404534-B1 | Method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin | XINGZHI COLLEGE ZHEJIANG NORMAL UNIVERSITY (CN) | 2025-09-02 | — | — | US | claimed |
| WO-1993025201-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES | BURZYNSKI STANISLAW R (US) | 1993-12-23 | — | — | WO | claimed |
| WO-1993024123-A1 | METHODS FOR TREATING VIRAL INFECTIONS | BURZYNSKI STANISLAW R (US) | 1993-12-09 | — | — | WO | claimed |
| EP-0567613-A1 | COMPOSITIONS AND METHODS FOR THERAPY AND PREVENTION OF CANCER, AIDS, AND ANEMIA | SAMID, Dvorit (US) | 1993-11-03 | — | — | EP | claimed |
| US-5244922-A | Methods for treating viral infections | BURZYNSKI STANISLAW R (US) | 1993-09-14 | — | — | US | claimed |
| WO-1993007866-A2 | COMPOSITIONS AND METHODS FOR THERAPY AND PREVENTION OF CANCER, AIDS, AND ANEMIA | SAMID DVORIT (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0288788-A2 | Preparation of linear polycarbonates from cyclic oligomer compositions using benzyl carbanion-generating catalyst | GENERAL ELECTRIC COMPANY (US) | 1988-11-02 | — | — | EP | claimed |
| US-4778875-A | PHENYLACETIC ACID OR SALTS THEREOF | GENERAL ELECTRIC COMPANY (US) | 1988-10-18 | — | — | US | claimed |
| CN-85100362-B | Method for synthesizing phenylacetic acid by low-pressure carbonylation | 吴惠民 | 1987-02-18 | — | — | CN | claimed |
| CN-85100362-A | METHOD FOR SYNTHESIZING PHENYLACETIC ACID BY LOW PRESSURE CARBONYLATION | — | 1986-07-16 | — | — | CN | claimed |
| US-4084061-A | REARRANGEMENT OF TOLYL OR CHLOROTOLYL SODIUM, CARBOXYLATION | IHARA CHEMICAL INDUSTRY CO., LTD. (JA) | 1978-04-11 | — | — | US | claimed |