Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | CYP27B1 | O15528 | 2/20 | 0.39 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426949 | 0.82 | GPR132 (0.47) | MAOAADAMTS4MAPK1IKBKB | |
| SCHEMBL22305118 | 0.78 | NOS3 (0.50) | MAOBNOS3NOS1NOS2MAOA | |
| SCHEMBL24301674 | 0.71 | SMN1; SMN2 (0.43) | MAOBNOS3NOS1NOS2CYP27B1 | |
| SCHEMBL840881 | 0.70 | MAPT (0.46) | SMN1; SMN2 | |
| SCHEMBL169752 | 0.68 | MAOB (0.54) | MAOBNOS3NOS1NOS2CYP27B1 | |
| SCHEMBL694419 | 0.68 | F2 (0.45) | MAOBNOS3NOS1NOS2CYP27B1 | |
| SCHEMBL18745401 | 0.68 | NOS3 (0.49) | MAOBNOS3NOS1NOS2CYP27B1 | |
| SCHEMBL7245835 | 0.68 | NOS3 (0.46) | MAOBNOS3NOS1NOS2CYP27B1 | |
| SCHEMBL14464039 | 0.68 | CYP27B1 (0.51) | MAOBCYP27B1CYP24A1ADAMTS4MMP13 | |
| SCHEMBL4858769 | 0.68 | PLK1 (0.48) | MAOBNOS3NOS1NOS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099891-A1 | Medicinal compositions and combinations | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-03 | — | — | US | disclosed |
| EP-1695706-A1 | MEDICINAL COMPOSITIONS AND COMBINATIONS | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2006-08-30 | — | — | EP | disclosed |
| US-6420381-B1 | ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1104763-A1 | NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099891-A1 | Medicinal compositions and combinations | HMGCR, APOB, CYP46A1 | MAOB 211/4885NOS3 398/4885NOS1 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.