Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429821 | 0.85 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4ETSHRKMT2A | |
| SCHEMBL5427285 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4ETSHRKMT2A | |
| SCHEMBL5433770 | 0.77 | MAPT (0.37) | ALDH1A1MAPTKDM4ETSHRKMT2A | |
| SCHEMBL5431215 | 0.75 | TRPV4 (0.45) | — | |
| SCHEMBL5429969 | 0.74 | USP2 (0.41) | ALDH1A1MAPTKDM4ETSHRKMT2A | |
| SCHEMBL5426870 | 0.73 | DOCK5 (0.55) | KMT2ADOCK5LIPE | |
| SCHEMBL5423163 | 0.73 | PROKR1 (0.35) | ALDH1A1DOCK5EGLN1 | |
| SCHEMBL5429876 | 0.72 | DOCK5 (0.49) | TSHRDOCK5LIPE | |
| SCHEMBL5427827 | 0.72 | DOCK5 (0.52) | TSHRDOCK5 | |
| SCHEMBL5423572 | 0.72 | L3MBTL1 (0.42) | MAPTDOCK5LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | ONO PHARMACEUTICAL CO., LTD. | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | NR3C2, CBR1, CBR3 | ALDH1A1 718/4885MAPT 4395/4885KDM4E 3460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.