Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meptazinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.97 |
| ▸ | ACHE | P22303 | 4/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meptazinol SCHEMBL25404 | 0.99 | ACHE (1.00) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL11947491 | 0.99 | ACHE (1.00) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL12125416 | 0.99 | ACHE (1.00) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL124401 | 0.97 | ACHE (0.97) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL1651915 | 0.96 | ACHE (0.95) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL3375335 | 0.92 | ACHE (0.86) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL542368 | 0.92 | ACHE (0.86) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL999304 | 0.92 | ACHE (0.86) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL3374823 | 0.90 | ACHE (0.82) | ACHESLC22A1CHRM2SLC6A4OPRM1 | |
| Meptazinol SCHEMBL11481015 | 0.90 | ACHE (0.82) | ACHESLC22A1CHRM2SLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270847-A1 | NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIATES AND USES THEREOF | SHIRE LLC (US) | 2012-10-25 | — | — | US | disclosed |
| EP-2413937-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | Shire LLC (US) | 2012-02-08 | — | — | EP | disclosed |
| EP-1962817-B1 | TRANSDERMAL DELIVERY OF A SALT FORM OF MEPTAZINOL | SHIRE PHARMACEUTICALS INC (US) | 2010-11-17 | — | — | EP | disclosed |
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2010112942-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100209483-A1 | TRANSDERMAL DELIVERY OF MEPTAZINOL | SHIRE PHARMACEUTICALS, INC. | 2010-08-19 | — | — | US | disclosed |
| US-20090186832-A1 | AMINO ACID PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF | SHIRE LLC (US) | 2009-07-23 | — | — | US | disclosed |
| WO-2009092071-A2 | AMINO ACID AND PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF | SHIRE LLC (US) | 2009-07-23 | — | — | WO | disclosed |
| EP-2061441-A2 | TRANSDERMAL DELIVERY OF MEPTAZINOL | Shire Pharmaceuticals, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1962817-A2 | TRANSDERMAL DELIVERY OF MEPTAZINOL | Shire Pharmaceuticals, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2008022128-A2 | TRANSDERMAL DELIVERY OF MEPTAZINOL | SHIRE PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20070224253-A1 | Transdermal Delivery of Meptazinol | SHIRE PHARMACEUTICALS INC. (US) | 2007-09-27 | — | — | US | disclosed |
| WO-2007075883-A9 | TRANSDERMAL DELIVERY OF MEPTAZINOL | SHIRE PHARMACEUTICALS INC (US) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007075883-A2 | TRANSDERMAL DELIVERY OF MEPTAZINOL | SHIRE PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | VIP, OPRL1, OPRK1 | OPRM1 4/4885ACHE 492/4885SLC22A1 1134/4885 |
| US-20070224253-A1 | Transdermal Delivery of Meptazinol | MEP1A, MEP1B, OPRL1 | OPRM1 20/4885ACHE 11/4885SLC22A1 1486/4885 |
| US-20100209483-A1 | TRANSDERMAL DELIVERY OF MEPTAZINOL | MEP1A, OPRL1, MEP1B | OPRM1 19/4885ACHE 6/4885SLC22A1 1313/4885 |
| US-20120270847-A1 | NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIATES AND USES THEREOF | OPRL1, OPRM1, DNPEP | OPRM1 2/4885ACHE 71/4885SLC22A1 1633/4885 |
| US-20090186832-A1 | AMINO ACID PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF | DNPEP, PEPD, PREP | OPRM1 42/4885ACHE 62/4885SLC22A1 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.