Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18456942 | 0.83 | HTR2A (0.36) | HTR2BHTR2AHTR2CALDH1A1HIF1A | |
| SCHEMBL23707669 | 0.78 | CES2 (0.50) | ALDH1A1HSD17B10MEN1MAPK1KMT2A | |
| SCHEMBL9140835 | 0.78 | CES2 (0.50) | ALDH1A1HSD17B10MEN1MAPK1KMT2A | |
| SCHEMBL4496746 | 0.77 | PBRM1 (0.39) | PBRM1HTR2BHTR2AHTR2CMEN1 | |
| SCHEMBL3756810 | 0.77 | CA1 (0.38) | PBRM1HTR2BHTR2CMEN1KMT2A | |
| SCHEMBL22276494 | 0.77 | CA1 (0.38) | PBRM1HTR2BHTR2CALDH1A1MAPK1 | |
| SCHEMBL23963013 | 0.77 | ADORA2A (0.37) | ALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL18826578 | 0.77 | CA1 (0.38) | HTR2BHTR2AHTR2CMEN1KMT2A | |
| SCHEMBL7825909 | 0.76 | ALDH1A1 (0.44) | ALDH1A1HSD17B10MEN1KMT2ALMNA | |
| SCHEMBL3374566 | 0.74 | ERN1 (0.37) | ALDH1A1MEN1KMT2ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070031514-A1 | Use of isoindolinone derivatives as insecticides | BAYER CROPSCIENCE AG (DE) | 2007-02-08 | — | — | US | disclosed |
| US-20070031514-A1 | Use of isoindolinone derivatives as insecticides | BAYER CROPSCIENCE AG (DE) | 2007-02-08 | — | — | US | disclosed |
| US-20070031514-A1 | Use of isoindolinone derivatives as insecticides | BAYER CROPSCIENCE AG (DE) | 2007-02-08 | — | — | US | disclosed |
| EP-1635639-A1 | USE OF ISOINDOLINONE DERIVATIVES AS INSECTICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110149-A1 | USE OF ISOINDOLINONE DERIVATIVES AS INSECTICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2004-12-23 | — | — | WO | disclosed |
| EP-0399818-B1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC (CA) | 1995-08-16 | — | — | EP | disclosed |
| US-5204358-A | Antiallergens; antiinflammatory agents; treatment of asthma, rhinitis, bronchitis and skin diseases | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| US-5104882-A | Leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-04-14 | — | — | US | disclosed |
| EP-0399818-A1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC. (CA) | 1990-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070031514-A1 | Use of isoindolinone derivatives as insecticides | DDT, CYP1A2, CYP1A1 | PBRM1 2946/4885HTR2B 1910/4885HTR2A 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.