Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 5/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9140835 | 1.00 | CES2 (0.50) | CES2MAOAMAOBALDH1A1MAPT | |
| SCHEMBL3756810 | 0.78 | CA1 (0.38) | CES2MEN1KMT2A | |
| SCHEMBL22276494 | 0.78 | CA1 (0.38) | CES2MAOAMAOBALDH1A1MAPK1 | |
| SCHEMBL5426438 | 0.78 | PBRM1 (0.39) | ALDH1A1HSD17B10HPGDMAPK1LMNA | |
| SCHEMBL23963013 | 0.78 | ADORA2A (0.37) | CES2MAOAMAOBALDH1A1TDP1 | |
| SCHEMBL4488117 | 0.78 | MAOA (0.53) | CES2MAOAMAOBALDH1A1MAPT | |
| SCHEMBL18826578 | 0.78 | CA1 (0.38) | CES2MAOAMAOBMAPTHTT | |
| SCHEMBL7606551 | 0.78 | CES2 (0.49) | CES2MAOAMAOBALDH1A1MAPT | |
| SCHEMBL7825909 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPTALOX15HSD17B10HPGD | |
| SCHEMBL9138249 | 0.76 | MAOA (0.50) | CES2MAOAMAOBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858837-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | The Regents of The University of Michigan (US) | 2021-08-04 | — | — | EP | disclosed |