Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.33 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12718595 | 0.78 | HTR2A (0.38) | PBRM1MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL4488117 | 0.77 | MAOA (0.53) | MAPK1SMN1; SMN2MAOAMAOBTSHR | |
| SCHEMBL4496694 | 0.77 | MAOA (0.34) | MAPK1MAOAMAOB | |
| SCHEMBL17671008 | 0.77 | MAOA (0.34) | MAPK1MAOAMAOB | |
| SCHEMBL1869956 | 0.77 | ADORA2A (0.37) | MAOAMAOBTSHRRECQL | |
| SCHEMBL5426438 | 0.77 | PBRM1 (0.39) | PBRM1MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL11542708 | 0.73 | ALDH1A1 (0.59) | PBRM1MEN1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL8809006 | 0.73 | PBRM1 (0.36) | PBRM1MEN1MAPK1KMT2ANPSR1 | |
| SCHEMBL1868789 | 0.72 | S100A4 (0.47) | KMT2ASMN1; SMN2MAOATSHRRECQL | |
| SCHEMBL16870455 | 0.70 | MAOA (0.47) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117327058-A | Synthesis method of 7- [ (4, 6-dimethyl-2-pyrimidinyl) thio ] -3-methyl-1 (3H) -isopropyl furanone | 顺毅南通化工有限公司 | 2024-01-02 | — | — | CN | disclosed |
| US-7528266-B2 | Chemical intermediates of byproduct-free 7-thio-3H-isobenzofuran-1-one derivatives and herbicidal 7-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methyl-3H-isobenzo-furan-1-one | SYNGENTA CROP PROTECTION, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-20080108813-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080097111-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-7307175-B2 | Process for the preparation of 7-substituted 3-alkyl-3H-isobenzofuran-1-one derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2007-12-11 | — | — | US | disclosed |
| US-20070191457-A1 | Compounds having activity at 5ht2c receptor and uses thereof | GLAXO GROUP LIMITED (GB) | 2007-08-16 | — | — | US | disclosed |
| US-20070191457-A1 | Compounds having activity at 5ht2c receptor and uses thereof | GLAXO GROUP LIMITED (GB) | 2007-08-16 | — | — | US | disclosed |
| US-20070191457-A1 | Compounds having activity at 5ht2c receptor and uses thereof | GLAXO GROUP LIMITED (GB) | 2007-08-16 | — | — | US | disclosed |
| EP-1611098-B1 | COMPOUNDS HAVING ACTIVITY AT 5HT2C RECEPTOR AND USES THEREOF | GLAXO GROUP LTD (GB) | 2006-12-27 | — | — | EP | disclosed |
| EP-1390339-B1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-02-01 | — | — | EP | disclosed |
| EP-1611098-A1 | COMPOUNDS HAVING ACTIVITY AT 5HT2C RECEPTOR AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004089897-A1 | COMPOUNDS HAVING ACTIVITY AT 5HT2C RECEPTOR AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2004-10-21 | — | — | WO | disclosed |
| US-20040158080-A1 | Process for the preparation of 7-substituted 3-alkyl-3h-isobenzofuran-1-one derivatives | SYNGENTA CROP PROTECTION, INC. | 2004-08-12 | — | — | US | disclosed |
| EP-1390339-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | Syngenta Participations AG (CH) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002094760-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191457-A1 | Compounds having activity at 5ht2c receptor and uses thereof | HTR4, HTR7, HTR2C | PBRM1 4354/4885MEN1 2379/4885MAPK1 3501/4885 |
| US-20080108813-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | C1S, CYP2S1, SULT2A1 | PBRM1 2575/4885MEN1 2452/4885MAPK1 2191/4885 |
| US-20080097111-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | C1S, C1R, C3AR1 | PBRM1 3767/4885MEN1 85/4885MAPK1 860/4885 |
| US-20040158080-A1 | Process for the preparation of 7-substituted 3-alkyl-3h-isobenzofuran-1-one derivatives | CBR1, AFF1, ALK | PBRM1 605/4885MEN1 2645/4885MAPK1 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.