Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 9/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27557523 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL16638704 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL24301594 | 0.77 | TLR4 (0.49) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL28153213 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL24726474 | 0.77 | SYK (0.45) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL5420966 | 0.76 | MAOB (0.41) | SMN1; SMN2MAOBMAOATLR4TLR2 | |
| SCHEMBL26580976 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL22967390 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL6445371 | 0.74 | KCNH2 (0.67) | KDM4EALDH1A1SMN1; SMN2PARP10SYK | |
| SCHEMBL21199309 | 0.73 | MAPT (0.59) | KDM4EALDH1A1SMN1; SMN2PARP10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099891-A1 | Medicinal compositions and combinations | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-03 | — | — | US | disclosed |
| EP-1695706-A1 | MEDICINAL COMPOSITIONS AND COMBINATIONS | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2006-08-30 | — | — | EP | disclosed |
| US-6420381-B1 | ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1104763-A1 | NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099891-A1 | Medicinal compositions and combinations | HMGCR, APOB, CYP46A1 | KDM4E 846/4885ALDH1A1 792/4885SMN1; SMN2 4298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.