Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423448 | 0.85 | SCD5 (0.50) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 | |
| SCHEMBL3549274 | 0.77 | ALDH1A1 (0.72) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 | |
| SCHEMBL4817503 | 0.72 | LMNA (0.71) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 | |
| SCHEMBL4817495 | 0.72 | LMNA (0.71) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 | |
| SCHEMBL3539489 | 0.69 | KMT2A (1.00) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 | |
| SCHEMBL3553134 | 0.69 | SMN1; SMN2 (0.97) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 | |
| SCHEMBL795975 | 0.68 | ALDH1A1 (0.56) | ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL5373284 | 0.68 | OPRM1 (0.60) | — | |
| SCHEMBL2701002 | 0.67 | ALDH1A1 (0.67) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 | |
| SCHEMBL3553965 | 0.67 | TSHR (1.00) | ALDH1A1LMNAUSP2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060629-A1 | Large conductance calcium-activated k channel opener | TANABE SEIYAKU CO., LTD. (JP) | 2007-03-15 | — | — | US | disclosed |
| EP-1675585-A2 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | TANABE SEIYAKU CO., LTD. (JP) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037271-A2 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | TANABE SEIYAKU CO., LTD. (JP) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060629-A1 | Large conductance calcium-activated k channel opener | KCNN3, KCNN1, KCNN2 | ALDH1A1 3603/4885LMNA 1830/4885USP2 3734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.