Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38660598 | 0.85 | BRD4 (0.57) | HTTCYP2C9CYP2D6BRD4ALDH1A1 | |
| SCHEMBL11217394 | 0.83 | SRC (0.48) | KIF11HTTCYP2C9CYP2D6HIF1A | |
| SCHEMBL9374736 | 0.80 | SRC (0.56) | CYP2D6MAPK1EPHX1LMNASMN1; SMN2 | |
| SCHEMBL1753679 | 0.79 | TSHR (0.48) | TYRALDH1A1SMN1; SMN2CA12CA1 | |
| SCHEMBL11458883 | 0.78 | BRD4 (0.44) | CYP2C9CYP2D6HIF1AKDM4EMAPK1 | |
| SCHEMBL10583234 | 0.78 | PARP10 (0.52) | EPHX1MAPTCA1CA2MEN1 | |
| SCHEMBL15447133 | 0.77 | MAPT (0.41) | HTTHIF1AKDM4EBRD4ALDH1A1 | |
| SCHEMBL7472615 | 0.76 | CES2 (0.47) | KIF11KMT2A | |
| SCHEMBL11213786 | 0.76 | KIF11 (0.48) | KIF11HTTCYP2C9CYP2D6HIF1A | |
| SCHEMBL9494308 | 0.75 | SRC (0.61) | KIF11HTTCYP2C9CYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232628-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2007-10-04 | — | — | US | disclosed |
| EP-1742924-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005108376-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232628-A1 | Calcilytic Compounds | SOST, CALCB, CALCR | KIF11 4374/4885HTT 4266/4885CYP2C9 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.