Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 10/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.56 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560286 | 0.91 | PTGS2 (0.57) | AKR1C3AKR1C2PTGS1PTGS2LMNA | |
| SCHEMBL5452320 | 0.91 | AKR1C3 (0.72) | AKR1C3AKR1C2PTGS1PTGS2LMNA | |
| SCHEMBL5559675 | 0.90 | PTGS2 (0.52) | AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL5558752 | 0.90 | PTGS2 (0.58) | AKR1C3AKR1C2PTGS1PTGS2NPSR1 | |
| SCHEMBL5442429 | 0.90 | PTGS1 (0.77) | AKR1C3AKR1C2PTGS1PTGS2LMNA | |
| SCHEMBL5559389 | 0.89 | PTGS2 (0.51) | PTGS2 | |
| SCHEMBL5554275 | 0.89 | PTGS2 (0.52) | AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL5559103 | 0.89 | PTGS2 (0.53) | AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL5554680 | 0.89 | PTGS2 (0.53) | AKR1C3AKR1C2PTGS1PTGS2 | |
| SCHEMBL5447387 | 0.88 | PTGS1 (0.63) | AKR1C3AKR1C2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481587-B2 | Substituted 2-(5-hydroxy-2-methyl-1H-indole-3-yl)acetic acids and ethers thereof and the use of same to treat viral diseases | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2013-07-09 | — | — | US | disclosed |
| US-8481587-B2 | Substituted 2-(5-hydroxy-2-methyl-1H-indole-3-yl)acetic acids and ethers thereof and the use of same to treat viral diseases | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2013-07-09 | — | — | US | disclosed |
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | ALLA CHEM, LLC. | 2011-09-22 | — | — | US | disclosed |
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | ALLA CHEM, LLC. | 2011-09-22 | — | — | US | disclosed |
| US-20070161698-A1 | Modulators of CRTH2 Activity | MICROBIA, INC. | 2007-07-12 | — | — | US | disclosed |
| US-7205329-B2 | Modulators of CRTH2 activity | MICROBIA, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20060135591-A1 | Modulators of CRTH2 activity | IRONWOOD PHARMACEUTICALS, INC. | 2006-06-22 | — | — | US | disclosed |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | IDO1, TPH1, FOXM1 | AKR1C3 53/4885AKR1C2 87/4885PTGS1 1860/4885 |
| US-20060135591-A1 | Modulators of CRTH2 activity | HRH2, HRH1, MRGPRX2 | AKR1C3 3064/4885AKR1C2 2503/4885PTGS1 189/4885 |
| US-20070161698-A1 | Modulators of CRTH2 Activity | HRH2, HRH1, MRGPRX2 | AKR1C3 3064/4885AKR1C2 2503/4885PTGS1 189/4885 |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | AKR1C3 577/4885AKR1C2 563/4885PTGS1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.