Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.49 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CCKAR | P32238 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30872059 | 0.79 | NPC1 (0.68) | RAB9AMAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL5440906 | 0.78 | CNR1 (0.50) | SMN1; SMN2AVPR2OXTRAVPR1APTGS2 | |
| Bromide SCHEMBL10012835 | 0.76 | RAB9A (0.50) | RAB9AMAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL5449238 | 0.75 | PTGS2 (0.48) | RAB9AMAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL8673615 | 0.74 | PTGS2 (0.62) | PTGS2CNR1PTGS1 | |
| SCHEMBL5440875 | 0.74 | CNR1 (0.55) | SMN1; SMN2LMNAPTGS2KDM4EHPGD | |
| SCHEMBL16469037 | 0.72 | CACNA1B (0.42) | RAB9AMAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL5445432 | 0.71 | GABRA2 (0.66) | MAPTPTGS2CNR1KMT2A | |
| SCHEMBL20253515 | 0.71 | PTGS2 (0.42) | RAB9AMAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL5450853 | 0.70 | CNR1 (0.51) | MAPTSMN1; SMN2LMNAPTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070191448-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191448-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191448-A1 | Ion channel modulators | SCION PHARMACEUTICALS, INC. | 2007-08-16 | — | — | US | disclosed |
| EP-1722786-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| EP-1723117-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005086902-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005086836-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | CACNA1B, CACNA1C, TRPV1 | RAB9A 1595/4885MAPT 490/4885SMN1; SMN2 661/4885 |
| US-20070191448-A1 | Ion channel modulators | CACNA1B, CACNA1C, TRPV1 | RAB9A 1595/4885MAPT 490/4885SMN1; SMN2 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.