Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.67 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | EGLN2 | Q96KS0 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18077064 | 0.78 | EGLN2 (1.00) | EGLN2 | |
| SCHEMBL24393353 | 0.70 | KDM4E (0.52) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL8124545 | 0.69 | KDM4E (0.51) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL22342534 | 0.69 | KDM4E (1.00) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL7708814 | 0.68 | DYRK1A (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL5096009 | 0.68 | EGLN2 (0.50) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL3175220 | 0.68 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL24392490 | 0.67 | KDM4E (0.48) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL2178398 | 0.67 | DYRK1A (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL612383 | 0.65 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGDGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070129383-A1 | Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2007-06-07 | — | — | US | disclosed |
| EP-1674454-A1 | SUBSTITUTED 2-AMINO- 1,2,4 TRIAZOLO 1,5-a PYRIMIDINE DERIVATIVE AND USE THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2006-06-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129383-A1 | Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof | ADORA1, ADORA2B, ADORA3 | KDM4E 3781/4885ALDH1A1 75/4885HPGD 1034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.