Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450092 | 0.81 | NPC1 (0.37) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL5446190 | 0.80 | SMN1; SMN2 (0.37) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL2946099 | 0.79 | TSHR (0.46) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL4265820 | 0.79 | CDC25A (0.53) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL5453566 | 0.78 | ALOX5 (0.39) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL2946398 | 0.75 | FFAR1 (0.39) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL5447485 | 0.75 | MAOB (0.38) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1243217 | 0.74 | RAB9A (0.47) | NPC1RAB9AKMT2AMEN1TP53 | |
| SCHEMBL4674381 | 0.73 | NOS1 (0.41) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL4675458 | 0.73 | NPC1 (0.39) | NPC1RAB9AKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123495-A1 | PYRROLO-NAPHTHYL ACIDS AND METHODS FOR USING THEM | WYETH (US) | 2007-05-31 | — | — | US | claimed |
| EP-1781641-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | Wyeth (US) | 2007-05-09 | — | — | EP | claimed |
| US-7186749-B2 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2007-03-06 | — | — | US | claimed |
| US-20060052349-A1 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2006-03-09 | — | — | US | claimed |
| WO-2006023864-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | WYETH (US) | 2006-03-02 | — | — | WO | claimed |
| US-20070123495-A1 | PYRROLO-NAPHTHYL ACIDS AND METHODS FOR USING THEM | WYETH (US) | 2007-05-31 | — | — | US | disclosed |
| EP-1781641-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | Wyeth (US) | 2007-05-09 | — | — | EP | disclosed |
| US-7186749-B2 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2007-03-06 | — | — | US | disclosed |
| US-20060052349-A1 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2006-03-09 | — | — | US | disclosed |
| WO-2006023864-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123495-A1 | PYRROLO-NAPHTHYL ACIDS AND METHODS FOR USING THEM | SERPINE1, SERPINC1, SERPINB1 | NPC1 934/4885RAB9A 2657/4885KMT2A 4479/4885 |
| US-20060052349-A1 | Pyrrolo-naphthyl acids and methods for using them | SERPINE1, SERPINC1, SERPINB1 | NPC1 934/4885RAB9A 2657/4885KMT2A 4479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.