Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.65 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28699989 | 0.87 | HTR6 (0.65) | HTR6ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6913555 | 0.79 | HTR6 (1.00) | HTR6ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL28252471 | 0.78 | HTR6 (0.45) | HTR6ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL3716259 | 0.78 | SMN1; SMN2 (0.46) | HTR6KDM4EPKMKMT2AGAA | |
| SCHEMBL2208523 | 0.77 | MEN1 (0.50) | KDM4EKMT2AHPGDHSD17B10 | |
| SCHEMBL5454671 | 0.76 | HTR6 (0.46) | HTR6ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL10405334 | 0.76 | ALDH1A1 (0.37) | HTR6TP53KDM4EPKMKMT2A | |
| SCHEMBL6069951 | 0.76 | CA2 (0.46) | PKMALDH1A1 | |
| SCHEMBL28330197 | 0.76 | HTR6 (0.46) | HTR6KDM4EPKMKMT2AGAA | |
| SCHEMBL27177203 | 0.76 | ELANE (0.39) | HTR6KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179161-A1 | Pyrazolopyrimidine compounds and their use in medicine | VERNALIS (CAMBRIDGE) LIMITED. (GB) | 2007-08-02 | — | — | US | claimed |
| EP-1608652-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE IN MEDICINE | Vernalis (Cambridge) Limited (GB) | 2005-12-28 | — | — | EP | claimed |
| WO-2004087707-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE IN MEDICINE | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2004-10-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179161-A1 | Pyrazolopyrimidine compounds and their use in medicine | ROS1, ALK, NOX1 | HTR6 3866/4885ABCC9 1258/4885ABCC8 1053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.