Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CCR9 | P51686 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5442944 | 0.88 | GRIK1 (0.52) | GRIK1GRIK2CYP11B1CYP11B2BACE1 | |
| SCHEMBL5442874 | 0.84 | PPARD (0.50) | BACE1 | |
| SCHEMBL5447426 | 0.84 | PGR (0.39) | MAOBMEN1KMT2ABACE1HTT | |
| SCHEMBL5446217 | 0.84 | ESR1 (0.46) | MDM2MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL5442953 | 0.82 | PPARG (0.49) | MDM2 | |
| SCHEMBL5455844 | 0.82 | SLC6A5 (0.46) | MAOBMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL5455835 | 0.81 | NR4A2 (0.48) | ACP1MAOBNPC1MAPT | |
| SCHEMBL5448677 | 0.81 | PPARG (0.61) | — | |
| SCHEMBL5455854 | 0.79 | ALOX5AP (0.40) | MAOBBACE1KDM4EHPGD | |
| SCHEMBL5448418 | 0.73 | CYP11B2 (0.55) | GRIK1GRIK2MEN1KMT2ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123495-A1 | PYRROLO-NAPHTHYL ACIDS AND METHODS FOR USING THEM | WYETH (US) | 2007-05-31 | — | — | US | disclosed |
| EP-1781641-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | Wyeth (US) | 2007-05-09 | — | — | EP | disclosed |
| US-7186749-B2 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2007-03-06 | — | — | US | disclosed |
| US-20060052349-A1 | Pyrrolo-naphthyl acids and methods for using them | WYETH (US) | 2006-03-09 | — | — | US | disclosed |
| WO-2006023864-A1 | PYRROLO-NAPHTHYL ACIDS AS PAI-1 INHIBITORS | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123495-A1 | PYRROLO-NAPHTHYL ACIDS AND METHODS FOR USING THEM | SERPINE1, SERPINC1, SERPINB1 | GRIK1 3694/4885GRIK2 4410/4885ACP1 1079/4885 |
| US-20060052349-A1 | Pyrrolo-naphthyl acids and methods for using them | SERPINE1, SERPINC1, SERPINB1 | GRIK1 3694/4885GRIK2 4410/4885ACP1 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.