Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.55 |
| ▸ | ALPL | P05186 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30689181 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL30689228 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL2228076 | 0.78 | NR1H2 (0.60) | SMN1; SMN2NPC1RAB9AALPLLMNA | |
| SCHEMBL18010783 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL6439983 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL27880002 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL2553549 | 0.74 | L3MBTL1 (0.66) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL23488391 | 0.74 | SMN1; SMN2 (0.53) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL4031573 | 0.72 | SMN1; SMN2 (0.51) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL8311588 | 0.72 | SMN1; SMN2 (1.00) | SMN1; SMN2TDP1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| EP-3843844-A1 | COMPOUNDS | UCL Business Ltd (GB) | 2021-07-07 | — | — | EP | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
| US-20070191395-A1 | Heterocyclic compounds having antifungal activity | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-08-16 | — | — | US | disclosed |
| EP-1717238-A1 | FUNGICIDAL HETEROCYCLIC COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | SMN1; SMN2 451/4885TDP1 1958/4885L3MBTL1 2093/4885 |
| US-20070191395-A1 | Heterocyclic compounds having antifungal activity | ERG28, MANBA, MAN2B1 | SMN1; SMN2 4277/4885TDP1 2121/4885L3MBTL1 3180/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | SMN1; SMN2 74/4885TDP1 2746/4885L3MBTL1 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.