Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5445836 | 0.90 | RAB9A (0.50) | RAB9ANPC1MITFMRGPRX4CES2 | |
| SCHEMBL29351426 | 0.79 | CES2 (0.74) | RAB9ANPC1MITFMRGPRX4CES2 | |
| SCHEMBL63427 | 0.79 | CES2 (0.74) | RAB9ANPC1MITFMRGPRX4CES2 | |
| SCHEMBL6827745 | 0.79 | CES2 (0.74) | RAB9ANPC1MITFMRGPRX4CES2 | |
| SCHEMBL5928254 | 0.79 | NPC1 (0.53) | RAB9ANPC1MITFMRGPRX4HSD17B2 | |
| SCHEMBL5447588 | 0.79 | PTGS1 (0.49) | KDM4EAKR1C3MTNR1AMTNR1BAKR1C2 | |
| SCHEMBL5450787 | 0.78 | ALDH1A1 (0.46) | RAB9ANPC1MRGPRX4KDM4ESMN1; SMN2 | |
| SCHEMBL10403563 | 0.78 | CES2 (0.71) | RAB9ANPC1MITFMRGPRX4CES2 | |
| Hydrochloric Acid SCHEMBL30142542 | 0.78 | CES2 (0.71) | RAB9ANPC1MITFMRGPRX4CES2 | |
| SCHEMBL1448094 | 0.78 | CES2 (0.71) | RAB9ANPC1MITFMRGPRX4CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123586-A1 | Nitroso derivatives of diphenylamine | MERCK PATENT GMBH (DE) | 2007-05-31 | — | — | US | claimed |
| EP-1687260-A1 | NITROSO DERIVATIVES OF DIPHENYLAMINE | MERCK PATENT GmbH (DE) | 2006-08-09 | — | — | EP | claimed |
| WO-2005051896-A1 | NITROSO DERIVATIVES OF DIPHENYLAMINE | MERCK PATENT GMBH (DE) | 2005-06-09 | — | — | WO | claimed |
| US-20070123586-A1 | Nitroso derivatives of diphenylamine | MERCK PATENT GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
| US-20070123586-A1 | Nitroso derivatives of diphenylamine | MERCK PATENT GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123586-A1 | Nitroso derivatives of diphenylamine | NOS3, CBR3, CBR1 | RAB9A 3830/4885NPC1 1832/4885MITF 4778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.