Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SMO | Q99835 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530432 | 0.87 | KCNK3 (0.76) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL30799014 | 0.87 | KCNK3 (0.76) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL1335468 | 0.85 | SIRT1 (0.81) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL19880777 | 0.83 | TP53 (0.65) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL4684343 | 0.83 | RAB9A (1.00) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL7386516 | 0.83 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL7457738 | 0.83 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL29466759 | 0.81 | GRIK1 (0.60) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL12259160 | 0.79 | SIRT1 (0.69) | NPC1RAB9AMEN1KMT2ASIRT1 | |
| SCHEMBL10495538 | 0.79 | RAB9A (0.66) | NPC1RAB9AMEN1KMT2ASIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249630-A1 | Phenethanolamine derivatives for treatment of respiratory diseases | GLAXO GROUP LIMITED (GB) | 2007-10-25 | — | — | US | disclosed |
| US-20050209338-A1 | Phenethanolamine derivatives for treatment of respiratory diseases | GLAXO GROUP LIMITED (GB) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209338-A1 | Phenethanolamine derivatives for treatment of respiratory diseases | PHOSPHO1, PNMT, PEBP1 | NPC1 1351/4885RAB9A 1424/4885MEN1 1655/4885 |
| US-20070249630-A1 | Phenethanolamine derivatives for treatment of respiratory diseases | PHOSPHO1, PNMT, PEBP1 | NPC1 1351/4885RAB9A 1424/4885MEN1 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.