Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 10/20 | 0.76 |
| ▸ | KCNK9 | Q9NPC2 | 7/20 | 0.76 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30799014 | 1.00 | KCNK3 (0.76) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL3673898 | 0.91 | KCNK3 (0.61) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL18410447 | 0.89 | HDAC1 (0.67) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL5455627 | 0.87 | NPC1 (0.70) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL2298254 | 0.87 | KCNK3 (1.00) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL27835354 | 0.86 | NQO2 (0.59) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL25872216 | 0.85 | KCNK3 (0.62) | KCNK3KCNK9RAB9ANPC1KMT2A | |
| SCHEMBL14715827 | 0.83 | KCNK3 (0.92) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL14715912 | 0.83 | KCNK3 (0.92) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL7303920 | 0.82 | KCNK9 (0.73) | KCNK3KCNK9RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1155278-A | Arylthio compounds as antibacteral and antiviral agents | WARNER LAMBERT CO (US) | 1997-07-23 | — | — | CN | claimed |
| EP-3052501-B1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2022-06-22 | — | — | EP | disclosed |
| US-20200231588-A1 | Bicyclic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. | 2020-07-23 | — | — | US | disclosed |
| US-10544149-B2 | Bicyclic alkyne derivatives and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2020-01-28 | — | — | US | disclosed |
| CN-105793262-B | Two cycloalkyne derivatives and application thereof | 新加坡科技研究局 | 2019-09-03 | — | — | CN | disclosed |
| US-20180194771-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-07-12 | — | — | US | disclosed |
| US-9884867-B2 | Bicyclic alkyne derivatives and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-02-06 | — | — | US | disclosed |
| US-20160229860-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2016-08-11 | — | — | US | disclosed |
| CN-105793262-A | Bicyclic alkyne derivatives and uses thereof | 新加坡科技研究局 | 2016-07-20 | — | — | CN | disclosed |
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| WO-2009016088-A1 | THE USE OF BENZAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| EP-1245554-B1 | Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same | JSR CORP (JP) | 2005-01-26 | — | — | EP | disclosed |
| US-6794480-B2 | POLYARYLENE-BASED COPOLYMER USEFUL AS PROTON-CONDUCTIVE MEMBRANE WHICH CAN BE USED AS ELECTRON FOR PRIMARY BATTERY, ELECTROLYTE FOR SECONDARY BATTERY, HIGH MOLECULAR SOLID ELECTROLYTE FOR FUEL CELL | JSR CORPORATION (JP) | 2004-09-21 | — | — | US | disclosed |
| US-20020177656-A1 | Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same | JSR CORPORATION (JP) | 2002-11-28 | — | — | US | disclosed |
| EP-1245554-A1 | Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same | JSR Corporation (JP) | 2002-10-02 | — | — | EP | disclosed |
| CN-1155278-A | Arylthio compounds as antibacteral and antiviral agents | WARNER LAMBERT CO (US) | 1997-07-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229860-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | MAPKAPK2, CAMKK2, MKNK2 | KCNK3 231/4885KCNK9 540/4885SIRT1 2903/4885 |
| US-10544149-B2 | Bicyclic alkyne derivatives and uses thereof | MAPKAPK2, MAP4K2, MKNK2 | KCNK3 206/4885KCNK9 505/4885SIRT1 3078/4885 |
| US-20180194771-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | MAPKAPK2, CAMKK2, MKNK2 | KCNK3 231/4885KCNK9 540/4885SIRT1 2903/4885 |
| US-20200231588-A1 | Bicyclic Heteroaryl Compounds | CYP3A43, CYP11B2, CYP2F1 | KCNK3 1755/4885KCNK9 2765/4885SIRT1 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.