Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2B | P41595 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852934 | 0.85 | HRH2 (0.50) | HRH2ALDH1A1NPSR1HTR2AHTR2C | |
| SCHEMBL4859672 | 0.81 | HSD11B1 (0.52) | CYP2C19DRD2TPSAB1PROKR1GFER | |
| SCHEMBL5202181 | 0.79 | HRH2 (0.49) | HRH2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL5204486 | 0.77 | MAPT (0.54) | HRH2ALDH1A1NPSR1HTR2AHTR2C | |
| SCHEMBL5203370 | 0.76 | HRH2 (0.47) | HRH2ALDH1A1NPSR1HTR2AHTR2C | |
| SCHEMBL5205779 | 0.76 | HRH2 (0.49) | HRH2ALDH1A1NPSR1HPGDHTR2A | |
| SCHEMBL5202293 | 0.76 | THRB (0.49) | HRH2ALDH1A1HTR2AHTR2CHTR2B | |
| SCHEMBL4858756 | 0.76 | SLC2A1 (0.49) | HRH2ALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL5204484 | 0.73 | SLC2A1 (0.47) | HRH2ALDH1A1NPSR1HTR2AHTR2C | |
| SCHEMBL5203382 | 0.73 | MAPT (0.46) | HRH2ALDH1A1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007501828-A | — | — | 2007-02-01 | — | — | JP | claimed |
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | claimed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | claimed |
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | disclosed |