Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741426 | 0.91 | — | — | |
| SCHEMBL4923326 | 0.67 | — | — | |
| Anisole SCHEMBL28311263 | 0.61 | CA4 (0.74) | ACHEALDH1A1CYP3A4 | |
| SCHEMBL19890970 | 0.60 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL11919886 | 0.60 | ALDH1A1 (0.48) | ACHEALDH1A1MEN1KMT2AKDM4E | |
| M-Xylene SCHEMBL18060576 | 0.59 | ACHE (0.46) | ACHELOXLOXL2KMT2AKDM4E | |
| SCHEMBL145855 | 0.59 | ALDH1A1 (0.62) | ACHEALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL68300 | 0.58 | — | — | |
| Methoxymethane SCHEMBL27501177 | 0.57 | ALDH1A1 (0.53) | ACHEALDH1A1CYP3A4 | |
| SCHEMBL12825411 | 0.57 | SMN1; SMN2 (0.39) | ALDH1A1CYP3A4MEN1KMT2APABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270428-A1 | Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders | GLAXO GROUP LIMITED (GB) | 2007-11-22 | — | — | US | disclosed |
| US-20070142411-A1 | Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |
| EP-1687001-A2 | USE OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS FOR THE TREATMENT OF SCHIZOPHRENIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-08-09 | — | — | EP | disclosed |
| EP-1687000-A2 | USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-08-09 | — | — | EP | disclosed |
| EP-1510519-B1 | Pharmaceutical compositions comprising 2,3-diarylpyrazolo[1,5-B]pyridazine derivatives | GLAXO GROUP LTD (GB) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005049034-A2 | USE OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS FOR THE TREATMENT OF SCHIZOPHRENIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005048999-A2 | USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |
| US-20050113377-A1 | 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase, 2 (COX-2) inhibitors | BESWICK PAUL J (GB) | 2005-05-26 | — | — | US | disclosed |
| EP-1510519-A1 | Pharmaceutical compositions comprising 2,3-diarylpyrazolo[1,5-B]pyridazine derivatives | GLAXO GROUP LIMITED (GB) | 2005-03-02 | — | — | EP | disclosed |
| US-6861429-B2 | 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-01 | — | — | US | disclosed |
| US-6831097-B2 | For therapy of pain, fever, inflammation of a variety of conditions and diseases | SMITHKLINE BEECHAM CORPORATION | 2004-12-14 | — | — | US | disclosed |
| EP-1369421-B1 | Pharmaceutical compositions comprising 2,3-Diaryl-pyrazolo[1,5-B]pyridazine derivatives | GLAXO GROUP LTD (GB) | 2004-11-03 | — | — | EP | disclosed |
| EP-1369421-A1 | Pharmaceutical compositions comprising 2,3-Diaryl-pyrazolo[1,5-B]pyridazine derivatives | GLAXO GROUP LIMITED (GB) | 2003-12-10 | — | — | EP | disclosed |
| EP-1032575-B1 | 2,3-DIARYL-PYRAZOLO(1,5-B)PYRIDAZINES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | GLAXO GROUP LTD (GB) | 2003-07-23 | — | — | EP | disclosed |
| US-20030040517-A1 | 2,3-Diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibirors | SMITHKLINE BEECHAM CORPORATION | 2003-02-27 | — | — | US | disclosed |
| US-20030008872-A1 | 2,3-Diaryl-pyrazolo[1,5-B]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors | BESWICK PAUL JOHN (GB) | 2003-01-09 | — | — | US | disclosed |
| US-6451794-B1 | 2,3-Diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2(COX-2) inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-09-17 | — | — | US | disclosed |
| EP-1032575-A1 | 2,3-DIARYL-PYRAZOLO(1,5-B)PYRIDAZINES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999012930-A1 | 2,3-DIARYL-PYRAZOLO[1,5-B]PYRIDAZINES DERIVATIVES, THEIR PREPA RATION AND THEIR USE AS CYCLOOXYGENASE 2 (COX-2) INHIBITORS | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270428-A1 | Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders | TPH2, PTGS2, PTGES2 | ACHE 610/4885ALDH1A1 396/4885CYP3A4 329/4885 |
| US-20050113377-A1 | 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase, 2 (COX-2) inhibitors | PTGER1, NCOA1, NCOR2 | ACHE 3286/4885ALDH1A1 983/4885CYP3A4 678/4885 |
| US-20030008872-A1 | 2,3-Diaryl-pyrazolo[1,5-B]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors | PTGS1, CBR1, PTGER1 | ACHE 3003/4885ALDH1A1 645/4885CYP3A4 167/4885 |
| US-20030040517-A1 | 2,3-Diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibirors | CBR1, CRHR1, CRHR2 | ACHE 2675/4885ALDH1A1 1038/4885CYP3A4 247/4885 |
| US-20070142411-A1 | Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders | PTGES2, PTGER2, PTGDR2 | ACHE 1831/4885ALDH1A1 112/4885CYP3A4 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.