Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28102820 | 0.87 | POLB (0.50) | HTTRAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL5464823 | 0.86 | HTT (0.47) | HTTFFAR2SMN1; SMN2LMNAKMT2A | |
| SCHEMBL5468474 | 0.83 | TBXAS1 (0.44) | KDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL5471617 | 0.78 | SMN1; SMN2 (0.48) | KDM4ERAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL11523349 | 0.74 | ALDH1A1 (0.56) | HTTRAB9ANPC1EPHX2SMN1; SMN2 | |
| SCHEMBL5479076 | 0.73 | LMNA (0.45) | HTTLMNAKMT2AMEN1POLB | |
| SCHEMBL29089510 | 0.72 | POLB (0.58) | HTTRAB9ACYP2C9SMN1; SMN2LMNA | |
| SCHEMBL17294670 | 0.68 | RAB9A (0.61) | HTTKDM4ERAB9ANPC1PKM | |
| SCHEMBL17294672 | 0.68 | RAB9A (0.61) | HTTKDM4ERAB9ANPC1PKM | |
| SCHEMBL17294682 | 0.68 | RAB9A (0.61) | HTTKDM4ERAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149605-A1 | Substituted pyrrole derivatives as hmg-coa reductase inhibitors | RANBAXY LABORATORIES LIMITED (IN) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149605-A1 | Substituted pyrrole derivatives as hmg-coa reductase inhibitors | HMGCR, CYP46A1, GRHPR | HTT 1966/4885KDM4E 909/4885RAB9A 1964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.