Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | QDPR | P09417 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473484 | 0.86 | NAMPT (0.62) | TDP1NAMPTALDH1A1 | |
| SCHEMBL5466920 | 0.84 | RAB9A (0.56) | NAMPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5460061 | 0.82 | MAPT (0.60) | NAMPTALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL14562979 | 0.81 | QDPR (0.53) | TDP1NAMPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5549910 | 0.81 | NPC1 (0.50) | TDP1NAMPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5452210 | 0.80 | RAB9A (0.55) | NAMPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL22324918 | 0.79 | SMN1; SMN2 (0.58) | NAMPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5469430 | 0.77 | NAMPT (0.47) | TDP1NAMPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5465649 | 0.76 | KMT2A (0.60) | NAMPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5452223 | 0.76 | TMPRSS2 (0.55) | NAMPTNPC1RAB9AMAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | TDP1 4071/4885NAMPT 324/4885ALDH1A1 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.