Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.40 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.39 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.39 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL811550 | 0.80 | KMT2A (0.49) | ALDH1A1KMT2ALMNATDP1MAPK1 | |
| SCHEMBL5465559 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KMT2ALMNATDP1MAPK1 | |
| SCHEMBL9696285 | 0.74 | ALDH1A1 (0.66) | ALDH1A1KMT2ALMNATDP1MAPK1 | |
| SCHEMBL4996696 | 0.72 | ALDH1A1 (0.64) | ALDH1A1KMT2ALMNATDP1L3MBTL1 | |
| SCHEMBL514512 | 0.72 | ALDH1A1 (0.59) | ALDH1A1KMT2ALMNATDP1MAPK1 | |
| SCHEMBL31648307 | 0.72 | ALDH1A1 (0.71) | ALDH1A1KMT2ALMNATDP1L3MBTL1 | |
| SCHEMBL30659698 | 0.72 | ALDH1A1 (0.71) | ALDH1A1KMT2ALMNATDP1L3MBTL1 | |
| SCHEMBL2491556 | 0.72 | ALDH1A1 (0.71) | ALDH1A1KMT2ALMNATDP1L3MBTL1 | |
| SCHEMBL8159847 | 0.71 | ALDH1A1 (0.57) | ALDH1A1KMT2ALMNATDP1MAPK1 | |
| SCHEMBL4641800 | 0.71 | ALDH1A1 (0.57) | ALDH1A1KMT2ALMNATDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070031526-A1 | Topical Deodorant Compositions Based on Hydroxycitric Acid | BIODERM RESEARCH (US) | 2007-02-08 | — | — | US | disclosed |
| US-20040185069-A1 | Hydroxycitric acid derivatives for body slimming and tone firming compositions | GUPTA SHYAM K (US) | 2004-09-23 | — | — | US | disclosed |