Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643617 | 1.00 | AKR1C3 (0.44) | AKR1C3CCR5EPHX2PTGS2PTGS1 | |
| SCHEMBL4915630 | 0.87 | EPHX2 (0.43) | CCR5EPHX2PTGS2PTGS1 | |
| SCHEMBL4915625 | 0.87 | EPHX2 (0.43) | CCR5EPHX2PTGS2PTGS1 | |
| SCHEMBL4975056 | 0.85 | PTGS2 (0.44) | PTGS2 | |
| SCHEMBL4977528 | 0.85 | PTGS2 (0.44) | PTGS2 | |
| SCHEMBL5494676 | 0.82 | CCR5 (0.46) | CCR5EPHX2PTGS2 | |
| SCHEMBL5490989 | 0.82 | CCR5 (0.46) | CCR5EPHX2PTGS2 | |
| SCHEMBL15578249 | 0.81 | CCR5 (0.48) | AKR1C3CCR5EPHX2PTGS2 | |
| SCHEMBL15578247 | 0.81 | CCR5 (0.48) | AKR1C3CCR5EPHX2PTGS2 | |
| SCHEMBL6339476 | 0.80 | PPARG (0.39) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294636-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| US-20070015788-A1 | N-(3-Aryl-3-substitutedphenylpropyl) piperidines or 8-azabicyclo[3.2.1]octanes that are additionally substituted with an optionally fused 5-member N-heterocycle; the compounds are modulators of CCR5 receptor activity and are used in treating diseases such as rheumatoid arthritis | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | US | disclosed |
| CN-1784393-A | Chemical compounds | ASTRAZENECA AB (SE) | 2006-06-07 | — | — | CN | disclosed |
| EP-1625120-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004099178-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015788-A1 | N-(3-Aryl-3-substitutedphenylpropyl) piperidines or 8-azabicyclo[3.2.1]octanes that are additionally substituted with an optionally fused 5-member N-heterocycle; the compounds are modulators of CCR5 receptor activity and are used in treating diseases such as rheumatoid arthritis | CCR5, CCR2, CX3CR1 | AKR1C3 888/4885CCR5 1/4885EPHX2 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.