Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 4/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456433 | 0.92 | PRMT5 (0.56) | PRMT5HTTTP53KMT2ATLR8 | |
| SCHEMBL5456471 | 0.82 | NOD1 (0.60) | PRMT5HTTTP53KMT2ANOD1 | |
| SCHEMBL5463793 | 0.82 | TLR8 (0.49) | PRMT5HTTKMT2ATLR8CASR | |
| SCHEMBL5453935 | 0.81 | TLR8 (0.66) | PRMT5HTTTLR8NOD1TNF | |
| SCHEMBL5463706 | 0.80 | PRMT5 (0.63) | PRMT5HTTTP53KMT2ATLR8 | |
| SCHEMBL5141398 | 0.78 | PRMT5 (0.56) | PRMT5HTTTP53KMT2ATLR8 | |
| SCHEMBL15595665 | 0.76 | POLB (0.69) | HTTTP53KMT2ATLR8CASR | |
| SCHEMBL5104145 | 0.75 | PRMT5 (1.00) | PRMT5HTTTP53KMT2ATLR8 | |
| SCHEMBL5453997 | 0.74 | TLR8 (0.53) | KMT2ATLR8ALDH1A1LMNAHPGD | |
| SCHEMBL16084470 | 0.72 | CDK9 (0.41) | HTTTP53KMT2ANOD1CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232673-A1 | 2-Imino-benzimidazoles | ABBOTT LABORATORIES | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232673-A1 | 2-Imino-benzimidazoles | CYP2C19, UGT2B7, UGT2B17 | PRMT5 2145/4885HTT 4363/4885TP53 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.